Immunity – Page 52

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity

3 de March de 202430 de January de 2024 by inmunoadmin

Tuft cells are central regulators of type 2 immunity in the intestine. Eshleman et al. reveal that commensal bacterial-derived butyrate restricts stem cell development into tuft cells through the epigenetic-modifying enzyme HDAC3. The microbiota can th…

Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

22 de January de 202422 de January de 2024 by Zhao Zhou, Jingfei Yao, Dongmei Wu, Xun Huang, Yushuang Wang, Xinmeng Li, Qiang Lu, Yifu Qiu

Aging induces cellular senescence of immune cells, yet the underlying mechanism is poorly understood. Here, Zhou et al. reveal that type 2 cytokine signaling protects macrophages from senescence by directly sustaining DNA repair. They further show that…