Innate immunity relies on the NLR family of cytosolic pattern recognition receptors to detect pathogenic and sterile insults. In this issue of Immunity, Kanneganti and colleagues review the evolution and molecular characteristics of NLRs and discuss th…
TLRs play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns. Despite their protective roles, aberrations in TLRs contribute to inflammatory and autoimmune disorders. Akira et al. offer insights into TLR dis…
Stress hormones can contribute to cancer progression, but how immune cells play a role in this process is unclear. In a recent study in Cancer Cell, He et al. showed that glucocorticoids potentiate metastasis by skewing neutrophils toward pro-tumorigen…
Tissue-innervating neurons communicate with local immune and non-immune cells to balance homeostasis and inflammation. Deng, Gillis, Kaplan, and Chiu review some of the most well-defined and compelling pathways by which peripheral neurons regulate auto…
Recent studies revealed the existence of common principles of innate immune mechanisms across kingdoms and between the innate and adaptive branches of immunity in vertebrates. Lemaitre et al. discuss some key concepts of innate immunity that have renew…
Activation of the peripheral immune system contributes to stress-related neuropsychiatric symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social avoidance is mediated by monocyte-derived MMP8 that remodels the extracellula…
IL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic…
Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation o…
The activation of the innate immune system and subsequent neuroinflammation are common hallmarks of all neurodegenerative diseases. Castro-Gomez and Heneka review the emerging evidence related to receptors implicated in the activation of innate immunit…
Signals from the innate immune system initiate and guide adaptive immune responses. Barton and colleagues recount key discoveries leading to the current understanding of this communication and discuss how variation in the signals generated from pattern…
