The discovery of naive CD4+ T cell transcriptional heterogeneity raises the question regarding its plasticity and the mechanisms that may perturb the basal state. Even et al. report that, in mice, helminth infection, but not commensal colonization, tra…
Non-classical monocytes (NCMs) are circulating phagocytes that patrol the vascular tree. Thierry et al. find that peripheral, rather than bone marrow, endothelial cells serve as the nurturing niche of NCMs. Adhesion of NCMs to endothelial cells facilit…
Whether stroke induces sustained pro-inflammatory and proatherogenic endothelial alterations in systemic vessels remains poorly understood. Liu et al. find that brain ischemia induces the persistent activation of endothelial Notch1 signaling in the per…
Interleukin (IL)-33 release is associated with cell death in the tumor microenvironment, and it has varied effects on tumor development and progression. In a model of squamous cell carcinoma, Erickson et al. show that cancer stem cells produce large on…
The mechanisms responsible for the age-related decline in remyelination are incompletely understood. Tiwari et al. demonstrate that epigenetic reprogramming via innate immune training with BCG vaccination or conditional deletion of HDAC1/2 in microglia…
The general guidelines directing immune cell residency within tissues are poorly understood. Here, Simon et al. define the epigenetic landscapes and transposable element accessibility of CD45+ immune cells from murine and human tissues. This resource p…
Epigenomic features steering CD8+ T cell heterogeneity across tissues has not yet been extensively explored. By profiling chromatin accessibility changes and gene expression in T cells derived from multiple organs, Buquicchio et al. reveal the epigenet…
Due to technical constraints, how memory T cells surveil the lung is not understood. Using intravital microscopy, van de Wall et al. demonstrate the unique surveillance properties of CD103+ TRM cells in the lungs of influenza-experienced mice. Upon ant…
Lassa fever causes thousands of deaths annually and lacks effective vaccines or therapies. Carr et al. use a non-replicative pseudovirus deep mutational scanning platform to determine how Lassa virus surface protein mutations affect cell entry and anti…
Antibiotics in early life increase the risk of subsequently developing asthma. Perdijk et al. show that depletion of the microbiome reduces systemic levels of the metabolite indole-3-propionic acid. This results in long-lasting mitochondrial damage wit…
