Nature Reviews Immunology, Published online: 03 December 2024; doi:10.1038/s41577-024-01121-6Endogenous self-peptides derived from CNS antigens are presented on MHC class II molecules at the borders of the CNS and expand suppressive po…
Nature Reviews Immunology, Published online: 29 November 2024; doi:10.1038/s41577-024-01120-7Sialylated IgG protects against severe influenza by inducing the transcriptional repressor REST, which dampens the inflammatory response and p…
Nature Reviews Immunology, Published online: 12 November 2024; doi:10.1038/s41577-024-01100-xThe oral mucosa is a critical barrier tissue that is continually exposed to pathogens, but antiviral immune responses in this tissue are poorl…
Nature Reviews Immunology, Published online: 11 November 2024; doi:10.1038/s41577-024-01105-6The basic-residue-rich sequence (BRS) is a common motif located in the cytoplasmic tail of most immunoreceptors. This Perspective highlights t…
Nature Reviews Immunology, Published online: 07 November 2024; doi:10.1038/s41577-024-01103-8This Review discusses how adipose tissue can regulate host immune function via the release of adipokines, including adiponectin, leptin and va…
Nature Reviews Immunology, Published online: 07 November 2024; doi:10.1038/s41577-024-01102-9Thirty years ago, Polly Matzinger introduced the ‘danger theory of immunity’, which proposed that danger and damage have a decisive role in im…
Nature Reviews Immunology, Published online: 31 October 2024; doi:10.1038/s41577-024-01099-1Single-cell multi-omic profiling has revealed how the immune system is established in the human embryo, mapping in unprecedented detail the eme…
Nature Reviews Immunology, Published online: 30 October 2024; doi:10.1038/s41577-024-01109-2Inflammation and fibrosis are linked to organ dysfunction. Two studies in Nature investigate the cross-talk between immune cells and fibroblast…
Nature Reviews Immunology, Published online: 28 October 2024; doi:10.1038/s41577-024-01107-4Blocking the RNase activity of IRE1α can convert ‘cold’ tumours to immunologically ‘hot’ ones that respond to chemo-immunotherapy.
Nature Reviews Immunology, Published online: 28 October 2024; doi:10.1038/s41577-024-01110-9Increased intratumoral acidity associated with a high-fat diet accelarates tumour growth through the acid-sensing receptor GPR65 on tumour-asso…
