Nature Reviews Immunology, Published online: 11 February 2026; doi:10.1038/s41577-026-01281-7Intestinal macrophages that support the enteric nervous system may be involved in the spread of α-synuclein pathology from the gut to the brain.
Nature Reviews Immunology, Published online: 10 February 2026; doi:10.1038/s41577-026-01278-2A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through …
Nature Reviews Immunology, Published online: 06 February 2026; doi:10.1038/s41577-026-01277-3A preprint by Yan et al. reports that local antibody production in germinal centres contributes to negative feedback on low-affinity B cells t…
Nature Reviews Immunology, Published online: 05 February 2026; doi:10.1038/s41577-026-01276-4Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring t…
Nature Reviews Immunology, Published online: 28 January 2026; doi:10.1038/s41577-026-01275-5A preprint by El-Daher et al. describes an interferonopathy-associated mutation in the chromatin remodeller ATRX, which identifies an unexpecte…
Nature Reviews Immunology, Published online: 27 January 2026; doi:10.1038/s41577-026-01274-6A preprint by Villazala-Merino et al. shows that allergen-specific memory B cells must re-enter germinal centres to differentiate into IgE-prod…
Nature Reviews Immunology, Published online: 23 January 2026; doi:10.1038/s41577-026-01266-6JAK inhibitors are typically used to suppress the immune system but have also been shown to enhance antitumour and antiviral immune responses. …
Nature Reviews Immunology, Published online: 21 January 2026; doi:10.1038/s41577-025-01262-2In this Review, Martín-Cófreces, Calzada-Fraile and Sánchez-Madrid describe the bidirectional communication that occurs at immune synapses, foc…
Nature Reviews Immunology, Published online: 21 January 2026; doi:10.1038/s41577-025-01262-2In this Review, Martín-Cófreces, Calzada-Fraile and Sánchez-Madrid describe the bidirectional communication that occurs at immune synapses, foc…
Nature Reviews Immunology, Published online: 19 January 2026; doi:10.1038/s41577-026-01272-8A new study shows that inflammation spreads from psoriatic skin to joint disease through the migration of skin myeloid precursors to the joints…
