Protect the periportals
Nature Reviews Immunology, Published online: 08 May 2024; doi:10.1038/s41577-024-01042-4Commensal bacteria induce liver macrophages that protect the tissue against inflammation.
NatureReviewsImmunology
Atypical chemokine receptors in the immune system
Nature Reviews Immunology, Published online: 07 May 2024; doi:10.1038/s41577-024-01025-5This Review from Comerford and McColl discusses recent advances that have been made in understanding the biology of the atypical chemokine receptor…
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Nature Reviews Immunology, Published online: 02 May 2024; doi:10.1038/s41577-024-01029-1An optimal immune response to influenza virus strikes a balance between protective antiviral immune mechanisms and detrimental immunopathology. Her…
Opportunities and challenges for T cell-based influenza vaccines
Nature Reviews Immunology, Published online: 02 May 2024; doi:10.1038/s41577-024-01030-8Compared with many other vaccines, current vaccines against influenza provide only limited protection. Here, the authors describe the challenges an…
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Nature Reviews Immunology, Published online: 29 April 2024; doi:10.1038/s41577-024-01027-3Here, Rongbin Zhou and colleagues review the different types of damage-associated molecular pattern (DAMP) that trigger sterile inflammation via …
Noncanonical inflammasome mediates BBB breakdown
Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01039-zWei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
FAS signalling pathway is crucial for CAR T cell persistence
Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01038-0A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
Engineering immune-evasive allogeneic cellular immunotherapies
Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01022-8Genome editing approaches can be used to confer immune-evasive properties to allogeneic cellular immunotherapies, with the aim of achieving persi…
Weaker skin immunity in males due to androgen effects on ILC2s
Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01036-2Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of dendritic cells…
Harnessing our lived experience for science communication
Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01037-1Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of vacc…