Chunhong Li N6-methyladenosine (m6A) is the most abundant post-transcriptional modification in eukaryotic mRNA, extensively involved in RNA splicing, export, stability, and translation. In recent years, accumulating evidence has demonstrated that m6A modification …
N6-methyladenosine (m6A) modification represents the most prevalent internal RNA modification and plays a pivotal role in regulating RNA metabolism and cellular function. As a major m6A demethylase, ALKBH5 not only orchestrates tumor cell proliferation…
RNA epigenetic modifications critically regulate gene expression, with 5-methylcytosine (m5C) emerging as an important mark in cancer biology. NSUN2, a key m5C methyltransferase, modifies diverse RNA species, thereby influencing RNA stability, processi…
CD8+ T cells play a pivotal role in antiviral and antitumor immunity, yet under chronic antigen stimulation, they progressively enter a functionally impaired “exhausted” state, characterized by loss of effector functions, sustained high expression of i…
N6-methyladenosine (m6A) is the most abundant internal RNA modification, orchestrated by writers, erasers, and readers. METTL14, a key component of the m6A methyltransferase complex, acts as a structural scaffold that ensures substrate recognition and …
Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression…
