Pregnancy-shaped donor-directed alloimmune recall in husband-to-wife kidney transplantation: an integrative mechanistic framework

Spousal living donation expands access to kidney transplantation. Husband-to-wife kidney transplantation (HTW) may have a distinct immunologic context when the recipient has had pregnancies with the current donor, because maternal exposure involves the…

B cell–derived exosomal tRNA-Pro-TGG served as a non-invasive biomarker and mediator of inflammation in progressive IgA nephropathy

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and a leading cause of end-stage renal disease globally. Although mesangial IgA deposition defines its pathology, this alone does not predict disease progression. Current biom…

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