Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity

J Clin Immunol. 2025 Sep 30;45(1):136. doi: 10.1007/s10875-025-01935-6. ABSTRACT Inborn errors of immunity (IEI) are a heterogeneous group of genetic disorders that disrupt the normal development and function of the immune system. These diseases not only increase susceptibility to infections but also significantly elevate the risk of developing malignancies and autoimmune diseases. The interplay between … Read more

Novel Insights into the Clinical Features, Genetic Spectrum and Clonal Evolution of Patients Carrying NLRP3 Mosaicism

J Clin Immunol. 2025 Sep 30;45(1):134. doi: 10.1007/s10875-025-01922-x. ABSTRACT NLRP3 mosaicism is a well-established mechanism causing the monogenic autoinflammatory disease named cryopyrin-associated periodic syndromes (CAPS). The number of reported patients with NLRP3 mosaicism is small, and the knowledge about the long-term disease behavior is limited. Herein we assembled the largest cohort of individuals with NLRP3 … Read more

A Novel Compound Heterozygous Mutation in the IL12RB1 Gene Causes Susceptibility To Mycobacterium Tilburgii Infection

J Clin Immunol. 2025 Sep 30;45(1):133. doi: 10.1007/s10875-025-01930-x. ABSTRACT Mendelian susceptibility to mycobacterial disease (MSMD) is a rare clinical syndrome that is characterized by selective vulnerability to intracellular pathogens. Deficiency in IL12RB1 is the most common type of MSMD but the heterogeneity of its clinical Manifestation Makes precise diagnosis difficult. Here, we report a previously … Read more

MEF2D regulates T-cell function via CD70-CD27 signaling and promotes immune evasion in hepatocellular carcinoma

J Immunol. 2025 Sep 29:vkaf228. doi: 10.1093/jimmun/vkaf228. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) stands as one of the most prevalent and fatal malignancies globally, posing a persistent challenge in its treatment due to immune evasion. We knocked down MEF2D in HCC cell lines and analyzed HCC tissues and cell lines by RNA sequencing, … Read more

Balancing IL-17-mediated protection and IFN-γ-driven pathology at mucocutaneous barriers. Lucas Dos Santos Dias

Trends Immunol. 2025 Sep 26:S1471-4906(25)00221-2. doi: 10.1016/j.it.2025.09.002. Online ahead of print. ABSTRACT Mucocutaneous surfaces rely on IL-17-producing lymphocytes to preserve barrier integrity and prevent bacterial and fungal overgrowth. Accordingly, genetic or pharmacological IL-17 deficiencies lead to mucocutaneous infections. Interferon (IFN)-γ mediates host defense against intracellular pathogens, but excessive mucosal IFN-γ activity can paradoxically impair epithelial … Read more

H3K9 acetylation-NF-κB-AP-1 nexus targeted by ITE limits TNF-α-induced MMP-9 expression in monocytic cells

J Immunol. 2025 Sep 27:vkaf240. doi: 10.1093/jimmun/vkaf240. Online ahead of print. ABSTRACT Matrix metalloproteinase 9 (MMP-9) plays a key role in the pathogenesis of inflammatory diseases and is upregulated by TNF-α. ITE (2-[1’H-indole-3′-carbonyl]-thiazole-4-carboxylic acid methyl ester) functions as an endogenous ligand for the aryl hydrocarbon receptor and is involved in inflammation. It is still uncertain … Read more

Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope

J Immunol. 2025 Sep 27:vkaf254. doi: 10.1093/jimmun/vkaf254. Online ahead of print. ABSTRACT Foxp3+ regulatory T (Treg) cells with antigen receptors (TCRs) specific for host peptides suppress autoimmunity. Paradoxically, Treg cells are also found in CD4+ T-cell populations specific for foreign (nonhost) peptides. We investigated the origin and function of these Treg cells in mice. Populations … Read more

Identification of cellular senescence-associated hub genes and molecular targeting mechanisms of thalidomide in lupus nephritis (LN). Guowen Zhang Yanting Li Dongfang Huang Lin Tan Wanting Li Huidi Peng Yunyun Ye Lu Jiang Jingjing Xie Ji Zhang Shengjin Cui a Department of Clinical Laboratory, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Chinab Department of Medical Administration, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Chinac Core Laboratory, Research Services Department, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China

Volume 58, Issue 1, December 2025.

NR4A nuclear receptor expression in human macrophages mediates apoptosis and controls Mycobacterium tuberculosis growth

J Immunol. 2025 Sep 26:vkaf252. doi: 10.1093/jimmun/vkaf252. Online ahead of print. ABSTRACT Tuberculosis (TB), a significant global health issue, needs novel therapeutic approaches to reduce its burden. Studying host-pathogen interactions provides new targets for host-directed therapeutics (HDTs). Nuclear receptors (NRs) are important master regulators of cellular function and bona fide drug targets. Herein, we identify … Read more

Emerging insights into mosaic errors of immunity. Willem Roosens

Trends Immunol. 2025 Sep 25:S1471-4906(25)00222-4. doi: 10.1016/j.it.2025.09.003. Online ahead of print. ABSTRACT Mosaic errors of immunity (MEI) encompass a group of immune disorders caused by somatic or gonosomal gene variants affecting hematopoiesis and immune function. Although the causal role of mosaicism in monogenic immune disorders has been recognized for over two decades, our understanding of … Read more

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