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A High Density of Impaired Tertiary Lymphoid Structures Is Associated with Higher Tumor Stage and Recurrence in Non-Muscle-Invasive Bladder Cancer

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Cancer Immunol Res. 2026 Aug 31. doi: 10.1158/2326-6066.CIR-26-0104. Online ahead of print. ABSTRACT Tertiary lymphoid structures (TLS) have emerged as critical immune niches within the tumor microenvironment across various cancers. However, their structural organization and functional roles in non-muscle-invasive bladder cancer (NMIBC) remain poorly characterized. In this study, we comprehensively characterized TLS in NMIBC using … Read more

Isoform‐Level Analysis Reveals Reproducible Early Changes in Transcript Usage During Human Vaccine Responses. [[{“value”:”Lennart Riemann, Ahmed Hassan, Swantje Hammerschmidt, Anja Schimrock, Gunnar Schmidt, Nataliya Di Donato, Reinhold Förster”}]]

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mRNA vaccination triggers an early, transient wave of altered transcript isoform usage peaking at 24 h and resolving by Day 14, affecting genes involved in innate immunity. Confirmed by long-read sequencing and reproduced across influenza, Ebola, and MVA-based vaccine cohorts, these results highlight a previously underappreciated feature of vaccine-induced transcriptional regulation. ABSTRACT Vaccine-induced transcriptional responses have … Read more

Cover Story: Eur. J. Immunol. 9’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Nanobodies specific for Vβ11 enable detection and noninvasive imaging of antigen-specific T cells in vivo

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J Immunol. 2026 Aug 29;215(9):vkag237. doi: 10.1093/jimmun/vkag237. ABSTRACT Through screening of a VHH phage display library constructed from an alpaca immunized with the recombinantly expressed murine myelin oligodendrocyte (MOG)-specific 2D2 T cell receptor (TCR), we identified nanobodies that reduced antigen-driven 2D2 T cell activation in vitro. Immunoblotting and staining confirmed TCRβ chain reactivity and Vβ11-associated … Read more

MyD88 Promotes Neutrophil Extracellular Trap Formation and Gut Leakiness After Ethanol and Burn Injury​Xiaoling Li on 29 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 29:qiag118. doi: 10.1093/jleuko/qiag118. Online ahead of print. ABSTRACT Myeloid differentiation primary-response protein 88 (MyD88), an adapter protein used by many Toll-like receptors (TLRs), plays a critical role in initiating inflammatory responses. Our laboratory has previously shown that alcohol intoxication combined with burn injury causes intestinal tissue damage and leakiness. This … Read more

Micrometastasis as a distinct immunobiological state and therapeutic target. Silvia Avalle

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Trends Immunol. 2026 Aug 28:S1471-4906(26)00189-4. doi: 10.1016/j.it.2026.07.010. Online ahead of print. ABSTRACT Metastasis is an inefficient cellular process in which most disseminated tumor cells fail to form secondary lesions in distant tissues due to hostile conditions, such as protective immune surveillance. The few cells that survive these threats can seed subclinical metastatic lesions, known as … Read more

Spatiotemporal dynamics of intestinal immune cells

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Curr Opin Immunol. 2026 Aug 27;102:102836. doi: 10.1016/j.coi.2026.102836. Online ahead of print. ABSTRACT Intestinal immunity is coordinated by the spatial organization and temporal regulation of immune cells within a complex, antigen-rich environment. In this review, we discuss the latest advances in our understanding of how these two fundamental dimensions together shape intestinal immune homeostasis. We … Read more

Neutrophil-T cell dynamics predict tuberculosis outcome. Maziar Divangahi

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Trends Immunol. 2026 Aug 27:S1471-4906(26)00226-7. doi: 10.1016/j.it.2026.08.010. Online ahead of print. ABSTRACT Most individuals infected with Mycobacterium tuberculosis never develop active disease, yet the airway immune events determining outcome remain poorly understood. Branchett and colleagues prospectively profiled bronchoalveolar lavage from recent tuberculosis contacts, revealing that progression reflects a dynamic competition between opposing local immune states … Read more

Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells​Jiongming He on 26 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 26:qiag119. doi: 10.1093/jleuko/qiag119. Online ahead of print. ABSTRACT Natural killer (NK) cells are active tumoricidal cells that inhibit esophageal cancer (EC) development, making them a prospective immunotherapeutic tool. Nonetheless, NK cells undergo both activation and exhaustion in the tumor microenvironment, but the related mechanisms have not been thoroughly understood. Using … Read more

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