inmunoadmin

Functional and Proteomic Profiles of CD3(+) Plasma‐Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors. [[{“value”:”Piotr Widlak, Jie Han, Alicja Gluszko, Justyna Mika, Aneta Zebrowska, Sujan Kumar Mondal, Marta Gawin, Yana G. Najjar, Joanna Polańska, Monika Pietrowska, Theresa L. Whiteside”}]]

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The graphical abstract illustrates MTEX-driven reprogramming of CD3(+) T cells in patients with melanoma. ABSTRACT Small extracellular vesicles (sEV) released by T cells play a key role in immune regulation. Immune capture with anti-CD3 antibodies was used to isolate and study T cell-derived CD3(+)sEV from the plasma of patients with melanoma (MPs) or healthy donors … Read more

Altered Peripheral and Synovial CD8+ T Cell Signatures Are Associated With Disease Activity in Female Early‐Stage Rheumatoid Arthritis. [[{“value”:”Lina Xu, Minghua Zhan, Zimo Wei, Shiran Dong, Fang Wang, Ziqin Zhao, Yudong Liu”}]]

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Sex-biased synovial immunity features enhanced CCL3/CCL4-mediated CD8+ T-cell infiltration in female early-onset RA. This immune signature correlates with disease activity and fuels joint inflammation in female ERA patients. ABSTRACT Rheumatoid arthritis (RA) exhibits significant sexual dimorphism, with females being two to three times more susceptible than males. CD8+ T cells are key effector immune cells … Read more

Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery. Hesham ElAbd

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Trends Immunol. 2026 Sep 7:S1471-4906(26)00216-4. doi: 10.1016/j.it.2026.08.003. Online ahead of print. ABSTRACT Certain human leukocyte antigen (HLA) alleles occur more often in people with immune-mediated inflammatory diseases (IMIDs) than in unaffected individuals, making HLA one of the strongest inherited contributors to IMID risk. Yet how these alleles promote disease remains unclear. We argue that HLA … Read more

Intestinal helminths skew dendritic cell development to counter the anti-helminth immune response. Anna T Andrusaite

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Mucosal Immunol. 2026 Sep 7:100402. doi: 10.1016/j.mucimm.2026.100402. Online ahead of print. ABSTRACT Intestinal dendritic cells (DC) orchestrate the adaptive immune response that balances protection against pathogens and tolerance towards harmless antigens. Yet, it remains largely unknown what molecular mechanisms underly this functional duality. Heligmosomoides polygyrus bakeri (Hpb) is a naturally occurring parasite in mice characterised … Read more

The post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma

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Cancer Immunol Res. 2026 Sep 4. doi: 10.1158/2326-6066.CIR-26-0472. Online ahead of print. ABSTRACT The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by restrained function of effector T cells that drives resistance to immunotherapy. While tumor-extrinsic stroma and myeloid cells have been shown to mediate PDAC immune evasion, the role of tumor-intrinsic post-transcriptional … Read more

The Modular CAR: Adapting T Cells without Reengineering Them

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Cancer Immunol Res. 2026 Sep 4:OF1-OF2. doi: 10.1158/2326-6066.CIR-26-0906. Online ahead of print. ABSTRACT The therapeutic potential of chimeric antigen receptor (CAR) T cells has long been limited by the static nature of the engineered receptor; once manufactured, the cell is committed to a single antigen, unable to respond to the immune evasion and antigen heterogeneity … Read more

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