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Distinct roles of PGE2 signaling via EP2 and EP4 in circulating pDCs: implications for immune modulation in the tumor microenvironment​Jorge Cuenca-Escalona on 21 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 21:qiaf034. doi: 10.1093/jleuko/qiaf034. Online ahead of print. ABSTRACT Dendritic cells (DCs) play a pivotal role in orchestrating adaptive immunity in response to environmental cues such as prostaglandin E2 (PGE2). Tumors are known to establish a microenvironment rich in PGE2. Tumor-derived PGE2 is regarded as mediator of regulatory features in DCs, … Read more

Epigenetic Regulation of CD8+ Effector T Cell Differentiation by PDCD5. [[{“value”:”Lixue Jin, Xin Zhang, Jingyi Wang, Yujia Wang, Ke Wang, Zhuolin Wang, Pingzhang Wang, Xiuyuan Sun, Jie Hao, Rong Jin, Dan Lu, Qing Ge”}]]

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In CD8+ T cells, PDCD5 is an activation-induced molecule that interacts with PRDM9, thereby promoting its nuclear translocation and facilitating the H3K4me3 modification of genes associated with effector differentiation. ABSTRACT Epigenetic modification plays a crucial role in establishing the transcriptional program that governs the differentiation of CD8+ effector T cells. However, the mechanisms by which … Read more

ICAM‐1 Is Overexpressed by Cancers and Negatively Impacts Antibody‐Based Therapies Including Antibody–Drug Conjugates. [[{“value”:”J. Bradford Kline, Luigi Grasso, Nicholas C. Nicolaides”}]]

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Tumor-produced ICAM-1 protein binds to IgG1 antibodies and suppresses their antibody-dependent cellular (ADCC) and complement-dependent (CDC) cytotoxicity against antigen-positive cells via reduced engagement with CD16a receptors on immune effector cells and C1q complement protein. This interaction also reduces antibody internalization that negatively affects antibody–drug conjugate cytotoxicity. ABSTRACT Humoral immunity utilizes antibodies and immune effector cells to … Read more

Foxp3+CD8+ regulatory T cells: bona fide Tregs with cytotoxic function. Shunqun Luo

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Trends Immunol. 2025 Mar 19:S1471-4906(25)00053-5. doi: 10.1016/j.it.2025.02.010. Online ahead of print. ABSTRACT Various mammalian CD8+ T cell subsets with regulatory properties are either formed through a thymus-dependent mechanism or induced under various experimental protocols and referred to as CD8+ regulatory T cells (Tregs). CD8+ Tregs maintain distinct functions in the presence of CD4+ Tregs. This … Read more

Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections. Luna Minute

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Trends Immunol. 2025 Mar 19:S1471-4906(25)00055-9. doi: 10.1016/j.it.2025.02.012. Online ahead of print. ABSTRACT The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections. These immunotherapies can activate a wide spectrum of immunological mechanisms, … Read more

Decoding microglial functions in Alzheimer’s disease: insights from human models. Chandrika Rao

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Trends Immunol. 2025 Mar 19:S1471-4906(25)00054-7. doi: 10.1016/j.it.2025.02.011. Online ahead of print. ABSTRACT Microglia, key orchestrators of the brain’s immune responses, play a pivotal role in the progression of Alzheimer’s disease (AD). Emerging human models, including stem cell-derived microglia and cerebral organoids, are transforming our understanding of microglial contributions to AD pathology. In this review, we … Read more

Exacerbated endoplasmic reticulum stress transmitted by endometrial stromal cells alters the conditioning of tolerogenic dendritic cells affecting trophoblast migration

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J Immunol. 2025 Mar 20:vkae065. doi: 10.1093/jimmun/vkae065. Online ahead of print. ABSTRACT Endometrial stromal cells acquire a secretory profile associated with endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) related to the onset of a sterile inflammatory response essential for sustaining embryo implantation. However, exacerbated stromal ERS/UPR is associated with reproductive complications. Given the … Read more

Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow

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J Immunol. 2025 Mar 20:vkaf021. doi: 10.1093/jimmun/vkaf021. Online ahead of print. ABSTRACT Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive. To this purpose, we generated a knock-in mouse line in which downstream of the coding … Read more

Early neutrophil responses are potential biomarkers to predict severe COVID-19 in adults​Ananya Singh on 20 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 20:qiaf035. doi: 10.1093/jleuko/qiaf035. Online ahead of print. ABSTRACT In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders against pathogens. In a Singaporean adult cohort, early neutrophil mediators … Read more

IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis

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J Immunol. 2025 Mar 19:vkae064. doi: 10.1093/jimmun/vkae064. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) mediate tissue homeostasis and repair. The function of the interleukin-7 receptor α (IL-7Rα) in nonlymphoid tissue Tregs is still unknown, although low expression of IL-7Rα is a widely accepted marker for Tregs. Here, we show that IL-33R (ST2)-expressing Tregs … Read more

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