inmunoadmin

Deficiency of Adenosine Deaminase 2 Masquerading as Behçet’s Disease: Phenotypic Mimicry with HLA-B*51 Positivity

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J Clin Immunol. 2025 Mar 17;45(1):83. doi: 10.1007/s10875-025-01876-0. ABSTRACT PURPOSE: Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease resulting from biallelic loss-of-function mutations in ADA2 gene. It has variable clinical manifestations, some of which can mimic Behçet’s disease (BD). Herein, we present a family of three siblings diagnosed with DADA2, two … Read more

Diagnosis, Characteristics, and Outcome of Selective Anti-polysaccharide Antibody Deficiencies In A Retrospective Cohort of 55 Adult Patients

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J Clin Immunol. 2025 Mar 17;45(1):82. doi: 10.1007/s10875-025-01874-2. ABSTRACT Selective anti-polysaccharide antibody deficiency (SPAD) predisposes to encapsulated bacterial infections. The diagnosis is challenging, and literature reports are scarce in adult patients, we therefore aim to describe the demographics, infectious complications, therapeutic strategies, and outcome of adult patients. We conducted a multicenter observational study involving 55 … Read more

Exploring the genetic mechanisms driving KIR diversification

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J Immunol. 2025 Mar 17:vkae047. doi: 10.1093/jimmun/vkae047. Online ahead of print. ABSTRACT Killer cell immunoglobulin-like receptors (KIRs) are key modulators of natural killer cell activity, displaying either activating or inhibitory potential upon recognition of major histocompatibility complex (MHC) class I molecules. The genomic organization of KIR genes is complex, involving copy number variation and allelic … Read more

IL-2Rα is dispensable for murine B cell development and humoral response

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J Immunol. 2025 Mar 17:vkae045. doi: 10.1093/jimmun/vkae045. Online ahead of print. ABSTRACT The cytokine IL-2 plays a pivotal role in the immune system, specifically in the proliferation of T, B, and NK cells. The alpha subunit of the IL-2 receptor, IL-2Rα (CD25), is known to regulate the expansion and differentiation of T lymphocytes. CD25 is … Read more

High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration

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J Immunol. 2025 Mar 17:vkaf024. doi: 10.1093/jimmun/vkaf024. Online ahead of print. ABSTRACT The prevalence of obesity and metabolic diseases have risen significantly over the past decades. Chronic inflammation in obesity is a link between obesity and secondary disease. While macrophages and monocytes are known to contribute to metabolic disease risk during diet exposure, little is … Read more

Hematopoietic MyD88 orchestrates the control of gut colonization by segmented filamentous bacteria. Marie Cherrier

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Mucosal Immunol. 2025 Mar 14:S1933-0219(25)00028-5. doi: 10.1016/j.mucimm.2025.03.002. Online ahead of print. ABSTRACT Host-microbiota cooperation is critical for successful intestinal homeostasis. The commensal segmented filamentous bacteria (SFB) are crucial for orchestrating the post-natal maturation of the host gut immune system and establishing a healthy state of physiological inflammation, which largely depends on their intimate attachment to … Read more

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Insights into pathogenesis and biomarkers of prognosis. Jane Andersen

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Semin Immunol. 2025 Mar 14;78:101944. doi: 10.1016/j.smim.2025.101944. Online ahead of print. ABSTRACT MOG antibody-associated disease (MOGAD), an inflammatory demyelinating pathology, is typically associated with the clinical phenotypes acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), or transverse myelitis (TM). The mainstay of diagnosis is detection of antibodies targeting oligodendrocyte-expressed MOG (MOG-IgG). MOG-IgG-mediated demyelination occurs via complement-dependent … Read more

Sex differences in age-related cardiac and splenic S100A9 and NLRP3 expression​Kathleen Pappritz on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 15:qiaf031. doi: 10.1093/jleuko/qiaf031. Online ahead of print. ABSTRACT Age is an important risk factor for cardiovascular diseases (CVD) and associated with a systemic, low-grade inflammation, so called “inflammaging”. We aimed to investigate the impact of age and sex on the inflammatory markers S100A9 and components of the NLRP3 inflammasome at … Read more

Afucosylated broadly neutralising antibodies targeting HIV envelope elicit enhanced NK cell-mediated cytotoxicity against HIV-infected CD4+ T cell and macrophage targets​Olivia Wilhelm on 14 de March de 2025 at 10:00

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J Leukoc Biol. 2025 Mar 15:qiaf033. doi: 10.1093/jleuko/qiaf033. Online ahead of print. ABSTRACT Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which can recognise diverse HIV-infected cell types. A panel of broadly neutralising antibodies … Read more

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