inmunoadmin

Intracellular C1q – an unexpected player in neuronal proteostasis. Erin E West

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Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016/j.it.2024.09.006. Online ahead of print. ABSTRACT Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts … Read more

Sensory nerves unlock the TOLL-7 gate for cancer spread. R K Subbarao Malireddi

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Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016/j.it.2024.09.005. Online ahead of print. ABSTRACT Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading … Read more

COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle. Elena Magrini

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Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016/j.it.2024.09.003. Online ahead of print. ABSTRACT Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin … Read more

Immunometabolic Chaos in Septic Shock.​ Deepmala Shrestha

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J Leukoc Biol. 2024 Sep 28:qiae211. doi: 10.1093/jleuko/qiae211. Online ahead of print. ABSTRACT Septic shock is associated with over 40% mortality. The immune response in septic shock is tightly regulated by cellular metabolism and transitions from early hyper-inflammation to later hypo-inflammation. Patients are susceptible to secondary infections during hypo-inflammation. The magnitude of the metabolic dysregulation … Read more

COVID-19 extracellular vesicles display heterogeneity based on viral and host RNA expression: implications for host immune response​. Esmeralda Juárez

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J Leukoc Biol. 2024 Sep 27:qiae212. doi: 10.1093/jleuko/qiae212. Online ahead of print. ABSTRACT Viral RNA and miRNAs released by immune cells contribute to inflammation in COVID-19 patients. Here, we investigated the role of SARS-CoV2 RNA and host miRNAs carried within extracellular vesicles (EVs) in modulating inflammation. EVs were classified as positive or negative depending on … Read more

Limited proteolysis of neutrophil granule proteins by the bacterial protease RgpB depletes neutrophil antimicrobial capacity​. Kelley N Cooper

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J Leukoc Biol. 2024 Sep 25:qiae209. doi: 10.1093/jleuko/qiae209. Online ahead of print. ABSTRACT Neutrophils are highly abundant in the gingival tissues where they play an essential role in immune homeostasis by preventing microbial invasion. Here, we show that the oral periodontal pathogen Porphyromonas gingivalis utilizes its cysteine proteases (gingipains) to disengage phagosomal antimicrobial capacity. Arginine … Read more

The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes. ​Zoe Möller-Ramon

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J Leukoc Biol. 2024 Sep 25:qiae208. doi: 10.1093/jleuko/qiae208. Online ahead of print. ABSTRACT A majority of genetically modified mice have been produced using 129 strain-derived embryonic stem cells (ESCs). Despite ample backcrosses with other strains, these may retain characteristic for 129 passenger mutations leading to confounding phenotypes unrelated to targeted genes. Here we show that … Read more

Dendritic cell-specific deletion of PKCδ in offspring of allergic mothers prevents the predisposition for development of allergic lung inflammation in offspring. ​Jacquelyn D Lajiness

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J Leukoc Biol. 2024 Sep 23:qiae207. doi: 10.1093/jleuko/qiae207. Online ahead of print. ABSTRACT In humans and in mice, maternal allergy predisposes offspring to development of allergy. In murine models, increased levels of maternal β-glucosylceramides are both necessary and sufficient for the development of allergic predisposition in offspring. Furthermore, increased numbers of CD11b+ dendritic cell subsets … Read more

Neonatal neutrophils exhibit reduced NLRP3 inflammasome activation. ​Lou Martha Wackerbarth

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J Leukoc Biol. 2024 Sep 23:qiae206. doi: 10.1093/jleuko/qiae206. Online ahead of print. ABSTRACT Newborns are at high risk to develop sepsis. This is linked to innate immune responses at birth which are not completely adapted to postnatal life. Neutrophils are key players of innate immunity and exhibit a marked ontogenetic regulation of their functionality. Here, … Read more

Blood immune profiles reveal a CXCR3/CCR5 axis of dysregulation in early sepsis. ​David Kealy

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J Leukoc Biol. 2024 Sep 23:qiae204. doi: 10.1093/jleuko/qiae204. Online ahead of print. ABSTRACT We report on a pilot study exploring whether blood immune signatures can reveal early specific indicator profiles for patients meeting sepsis criteria upon hospital admission. We analysed samples of sepsis-suspected patients (N=20) and age-spanning healthy controls (N=12), using flow cytometry-based assays. We … Read more

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