inmunoadmin

Interferon-β treatment reverses the detrimental effect of B-cell depletion therapy on respiratory virus infection

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J Immunol. 2025 May 7:vkaf085. doi: 10.1093/jimmun/vkaf085. Online ahead of print. ABSTRACT Disease-modifying therapies (DMTs) are critical for managing autoimmunity such as multiple sclerosis (MS), yet concerns exist regarding their impact on viral infections. B-cell depletion (α-CD20) and IFN-β are 2 DMTs with seemingly opposing effects on viral infections. Pre-vaccine COVID-19 data linked B-cell depletion … Read more

TAP-independent induction of N-myristoylated lipopeptide-specific CTLs in transgenic mice expressing the rhesus MHC class I allomorph, Mamu-B*098

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J Immunol. 2025 May 7:vkaf082. doi: 10.1093/jimmun/vkaf082. Online ahead of print. ABSTRACT A novel subset of classical major histocompatibility complex class I molecules has recently been identified in rhesus monkeys that mediates the presentation of N-myristoylated lipopeptides, rather than conventional peptides, to CD8+ cytotoxic T lymphocytes (CTLs). For example, the rhesus Mamu-B*098 allomorph binds an … Read more

Quality of Life in Japanese Patients with Primary Immunodeficiency Disease is Disrupted throughout the Year

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J Clin Immunol. 2025 May 7;45(1):90. doi: 10.1007/s10875-025-01869-z. ABSTRACT Patients with primary immunodeficiency disease (PID) have an increased susceptibility to infection and may experience negative impacts on health-related quality of life (HR-QOL) and activities of daily living. This prospective observational study of patients aged ≥ 12 years with PID assessed HR-QOL, work impairment, and disease-related … Read more

CD27 costimulation supports metabolic fitness of CD4+ T cells by enhancing de novo nucleotide and protein synthesis

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J Immunol. 2025 May 5:vkaf075. doi: 10.1093/jimmun/vkaf075. Online ahead of print. ABSTRACT T cells undergo many metabolic changes throughout the different phases of their response in lymphoid and nonlymphoid tissues. Cell metabolism meets demands for energy and biosynthesis, particularly during cell division and effector differentiation. As costimulatory receptors, CD28 and various TNF receptor (TNFR) family … Read more

Diet-Induced dyslipidemia enhances IFN- γ production in mycolic Acid-Specific T cells and affects mycobacterial control. Yen-Lin Lin

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Mucosal Immunol. 2025 May 3:S1933-0219(25)00047-9. doi: 10.1016/j.mucimm.2025.04.009. Online ahead of print. ABSTRACT Dyslipidemia, characterized by altered lipid profiles, influences host immune responses against infections, including Mycobacterium tuberculosis (Mtb). While the effects of dyslipidemia on conventional T cell responses are well documented, its impact on group 1-CD1 restricted T cells, a distinct subset of lipid antigen-specific … Read more

Somatic mutations in HLA class genes and antigen presenting molecules in malignant glioma

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Cancer Immunol Res. 2025 May 5. doi: 10.1158/2326-6066.CIR-24-0419. Online ahead of print. ABSTRACT Immune evasion is a hallmark of gliomas, yet the genetic mechanisms by which tumors escape immune surveillance remain incompletely understood. In this study, we systematically examined the presence of somatic mutations in human leukocyte antigen (HLA) genes and genes encoding proteins involved … Read more

USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

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Cancer Immunol Res. 2025 May 5. doi: 10.1158/2326-6066.CIR-24-1194. Online ahead of print. ABSTRACT Colorectal cancer (CRC) creates a suppressive tumor immune microenvironment (TIME) which leads to tumor progression and resistance to immune checkpoint inhibitor (ICI) therapy. Ubiquitin-specific peptidase 15 (USP15) broadly regulates immune responses and immune cell differentiation, but its involvement in shaping the TIME … Read more

Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection. Rohin Chakraborty

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Mucosal Immunol. 2025 May 2:S1933-0219(25)00046-7. doi: 10.1016/j.mucimm.2025.04.008. Online ahead of print. ABSTRACT Influenza A virus (IAV) infections trigger asthma attacks and cause airway hyperresponsiveness (AHR) in murine models. However, the mechanism by which AHR is induced remains to be fully elucidated. Here, we show that targeting the interleukin (IL)-33 suppression of tumorigenicity 2 (ST2) receptor … Read more

Site-specific labeling uncovers differences in levels and distribution of B-cell receptors of different isotypes on primary B cells

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J Immunol. 2025 May 2:vkaf062. doi: 10.1093/jimmun/vkaf062. Online ahead of print. ABSTRACT Expression of the BCR is essential for survival, development, and effector functions of B cells. Naive B cells express surface IgM and IgD, while surface IgG1 is expressed by class-switched (memory) B cells. Despite similar overall structures, the different BCR isotypes show differences … Read more

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