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Chinese Herbal Extracts Mediated Programmed Cell Death in Cancer and Inflammation Therapy​Haihong Yu on 2 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 2:qiaf051. doi: 10.1093/jleuko/qiaf051. Online ahead of print. ABSTRACT Programmed cell death (PCD) is a common phenomenon in the development of organisms. It is an active and orderly mode of cell death determined by genes. PCD is usually classified into three different types according to the cell morphological changes, stimulus and … Read more

Secretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells​Zachary Kraus on 2 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 2:qiaf054. doi: 10.1093/jleuko/qiaf054. Online ahead of print. ABSTRACT Several human lymphocyte subsets express the novel secretory IgA receptor FCRL3. Secretory IgA binding to FCRL3 diminishes the inhibitory capacity of regulatory T cells and promotes a Th17-like phenotype. Here we report that in CD4+ regulatory T cells and CD8+ terminal effector … Read more

Advances in genetic-immunological targeted therapies for psoriasis

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Curr Opin Immunol. 2025 Apr 30;94:102559. doi: 10.1016/j.coi.2025.102559. Online ahead of print. ABSTRACT Psoriasis is a common chronic immune-mediated inflammatory skin disease, with its pathogenesis involving genetic susceptibility, abnormal immune responses, and environmental factors. In recent years, targeted immunotherapy has become a prominent treatment approach. Various drugs targeting cytokines, such as interleukin-17, interleukin-23, and tumor … Read more

Micellar formulation provides potent and tolerable TLR7 agonist treatment for anti-cancer immunotherapy

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J Immunol. 2025 Apr 30:vkaf043. doi: 10.1093/jimmun/vkaf043. Online ahead of print. ABSTRACT Immunostimulants can be highly effective anti-cancer therapeutics; however, their systemic use is often limited by adverse reactions (AEs). Formulating immunostimulants into nanoparticle systems can potentially alleviate these, but nanoparticle design is key. In previous studies, we encountered anti-nanoparticle reactions with systemically administered PEGylated … Read more

Porcine respiratory coronavirus as a model for acute respiratory disease: mechanisms of different infection outcomes

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J Immunol. 2025 Apr 30:vkaf066. doi: 10.1093/jimmun/vkaf066. Online ahead of print. ABSTRACT Porcine respiratory coronavirus (PRCV) is a naturally occurring pneumotropic coronavirus in the pig, providing a valuable large animal model to study acute respiratory disease. PRCV pathogenesis and the resulting immune response were investigated in pigs, the natural large animal host. We compared 2 … Read more

Global aspects of celiac disease and food allergy. Samagra Agrawal

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Semin Immunol. 2025 Apr 28;78:101961. doi: 10.1016/j.smim.2025.101961. Online ahead of print. ABSTRACT Celiac disease and food-allergy are both food-related chronic immune disorders with a common pathogenic link being breakdown in the gut tolerance to otherwise innocuous food antigens. Notwithstanding the similarities, there are significant differences in the pathogenesis of both disorders, which translates to variations … Read more

METTL3 inhibition restores PD-L1 expression and CD8+ T-cell cytotoxic function in immunotherapy treated gastric cancer

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Cancer Immunol Res. 2025 Apr 29. doi: 10.1158/2326-6066.CIR-24-1179. Online ahead of print. ABSTRACT The efficacy of immunotherapy targeting PD-1/PD-L1 in gastric cancer (GC) depends on PD-L1 expression level and infiltration of immune cells within the tumor microenvironment (TME). While methyltransferase-like 3 (METTL3) plays a role in the development and progression of GC, its mechanism of … Read more

CAR Binders Affect CAR T-cell Tonic Signaling, Durability, and Sensitivity to Target

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Cancer Immunol Res. 2025 Apr 29:OF1-OF14. doi: 10.1158/2326-6066.CIR-24-1347. Online ahead of print. ABSTRACT Patients can develop human anti-mouse immune responses against CD19-specific chimeric antigen receptor (CAR) T cells due to the use of a murine CD19-specific single-chain variable fragment to redirect T cells. We screened a yeast display library to identify an array of fully … Read more

The pathogenesis of neurological immune-related adverse events following immune checkpoint inhibitor therapy. Magdalena Lerch

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Semin Immunol. 2025 Apr 27;78:101956. doi: 10.1016/j.smim.2025.101956. Online ahead of print. ABSTRACT Cancer is a leading cause of morbidity and mortality worldwide. The development of immune checkpoint inhibitors (ICI) has revolutionised cancer therapy, and patients who were previously incurable can now have excellent responses. These therapies work by blocking inhibitory immune pathways, like cytotoxic T … Read more

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