inmunoadmin

Dimethyl fumarate (DMF) inhibits T-cell proliferation and induces apoptosis by depleting glutathione (GSH) and accumulating reactive oxygen species (ROS). Here, we show that DMF-induced oxidative stress disrupts multiple cell-signaling pathways, including MYC, leading to cell cycle arrest and impaired proliferative responses in activated T-cells. ABSTRACT Recent evidence indicates that the TCA cycle metabolite fumarate plays … Read more

The evolution of the concept of the immune system from a set of composed cells and tissue that defend the host from exogenous agents into a system that has regulatory and homeostatic functions determined by the interaction with microorganisms as a functional part of an extended immune system, that we call symmunobiome. ABSTRACT The immune … Read more

The RNA-binding proteins ZFP36L1 and ZFP36L2 regulate in T cells the production of the key effector molecules TNF, IL-2, and IFNγ. Genetic deletion of ZFP36L1 and ZFP36L2 induces superior cytokine production in continuously activated tumor-infiltrating lymphocytes. However, ZFP36L1+ZFP36L2-deficient T cells exhibit reduced cell fitness: they more frequently undergo apoptosis, potentially due to disrupted cell cycle … Read more

The supernatant of M. tuberculosis-stimulated B cells promotes monocyte polarization toward an anti-inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ phenotype via an IL-6/STAT3 pathway. Confirmed with B cells from TB patients, this pathway impairs monocyte proinflammatory functions and may contribute to immune suppression in tuberculosis. Created in BioRender. Neyrolles, O. (2025) https://BioRender.com/930ras3 ABSTRACT The polarization of the monocyte/macrophage compartment toward an … Read more