inmunoadmin

Analysis of the T-cell epitope landscape of SARS-CoV-2 suggests T-cell intrinsic factors as likely modulators of disease severity and that the capacity of MHC-peptide presentation remains stable among circulating SARS-CoV-2 viral strains. ABSTRACT Infection with SARS-CoV-2 results in mild to severe COVID-19 disease courses. Several studies showed the association of impaired T-cell responses and certain … Read more

Probiotics administered to pregnant mice led to increased frequencies of IL17-committed Vγ6⁺ γδ T cells in the neonatal lung. This highlights a microbiota-sensitive pathway where maternal probiotics enhance γδ17 commitment in the perinatal lung. ABSTRACT The early life period is increasingly being recognized as a window of opportunity to shape immunity, where microbiota and related … Read more

A gluten-free diet prevents Type I diabetes in NOD mice. We characterized T cells from prediabetic mice on gluten-free or standard diets using flow cytometry and single-cell transcriptomics. A gluten-free diet enhanced T-cell activation and effector differentiation, including regulatory T cells, suggesting immune modulation as a mechanism for diabetes prevention. ABSTRACT Nonobese diabetic (NOD) mice … Read more

In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.