inmunoadmin

B-cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells

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J Immunol. 2025 Oct 13:vkaf282. doi: 10.1093/jimmun/vkaf282. Online ahead of print. ABSTRACT B cells have been shown to be phagocytic under some circumstances. However, the phagocytic capacity of different B-cell subsets and how this is linked to antigen (Ag) presentation or other functions has not been characterized. To address this, we developed 2-µm phagocytic Ag-conjugated … Read more

Single-cell clonal lineage tracing identifies the transcriptional program controlling the cell-fate decisions by neoantigen-specific CD8+ T cells

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Cancer Immunol Res. 2025 Oct 13. doi: 10.1158/2326-6066.CIR-25-0203. Online ahead of print. ABSTRACT Neoantigen-specific T cells recognize tumor cells and are critical for cancer immunotherapies to be effective. However, the transcriptional program controlling the cell-fate decisions by neoantigen-specific T cells is incompletely understood. Here, using joint single-cell transcriptome and T-cell receptor (TCR) profiling, we mapped … Read more

IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy

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Cancer Immunol Res. 2025 Oct 13. doi: 10.1158/2326-6066.CIR-24-1259. Online ahead of print. ABSTRACT Natural killer (NK) cells play a critical role in anti-cancer immunity through their direct cytotoxicity and production of cytokines, such as Flt3L. NK cell production of Flt3L controls conventional type I dendritic cell (cDC1) abundance in the tumor and promotes protective immune … Read more

Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity

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J Immunol. 2025 Oct 12:vkaf249. doi: 10.1093/jimmun/vkaf249. Online ahead of print. ABSTRACT Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin inflammation and identified a surprising type I interferon (IFN)-mediated activation of hematopoietic stem/progenitor … Read more

Deciphering and harnessing gut microbiota-associated immune regulation in acute graft-versus-host disease

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Curr Opin Immunol. 2025 Oct 10;97:102676. doi: 10.1016/j.coi.2025.102676. Online ahead of print. ABSTRACT Allogeneic hematopoietic stem cell transplantation represents a curative treatment of choice for numerous severe hematological malignancies. While donor-derived transplanted T cells can limit disease relapse (GvT/GvL effect), they also induce, in 30-50% of the patients, acute graft-versus-host disease (aGvHD), a severe condition … Read more

Optimizing post-transplantation cell therapies to enhance graft-versus-leukemia effects in hematological malignancies

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Curr Opin Immunol. 2025 Oct 10;97:102675. doi: 10.1016/j.coi.2025.102675. Online ahead of print. ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) can cure patients with high-risk hematologic malignancies. Donor T and natural killer (NK) cells contribute to graft-versus-leukemia (GVL) effects that provide relapse protection. Post-HCT relapses often represent inadequate GVL, but alloreactive lymphocytes that confer GVL may also … Read more

Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury. Sarah Berger

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00105-9. doi: 10.1016/j.mucimm.2025.10.003. Online ahead of print. ABSTRACT Acute lung injury is a common complication of pneumonia, with disease severity linked to inflammatory cell recruitment and lung barrier dysfunction. In this study, we investigate the role of neutrophil-chemoattractant CXCL5 in lung barrier function and inflammation. We examined CXCL5 in patients with … Read more

Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss. Skye Y Tracey

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00104-7. doi: 10.1016/j.mucimm.2025.10.002. Online ahead of print. ABSTRACT The upper airway is comprised of two distinct mucosal surface tissues, the respiratory mucosa (RM) and the olfactory mucosa (OM), both of which are constantly being exposed to airborne pathogens. The olfactory mucosa is responsible for detecting and conveying odorant information into the … Read more

Epididymitis promotes formation of tertiary lymphoid organs in the cauda epididymidis. Hiba Hasan

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00103-5. doi: 10.1016/j.mucimm.2025.10.001. Online ahead of print. ABSTRACT Uropathogenic Escherichia coli is a common pathogen that affects the cauda epididymidis, causing interstitial edema, epithelial damage, leukocyte infiltration, and fibrosis. Despite antibiotic treatment, up to 20 % of patients develop abscesses in the cauda epididymidis, and 40 % experience low sperm counts. … Read more

The epidermal immune microenvironment plays a central role in the pathogenesis of psoriasis

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Curr Opin Immunol. 2025 Oct 9;97:102674. doi: 10.1016/j.coi.2025.102674. Online ahead of print. ABSTRACT Psoriasis is a chronic immune-mediated skin disease whose inflammation can affect other systems and lead to various comorbidities. As a model inflammatory skin disease, while advances in mechanistic insights and targeted therapies have improved outcomes, unmet clinical needs persist. Modern technologies like … Read more

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