inmunoadmin

Cytometric Atlas of Combination Immunotherapy in Pancreatic Cancer: Blood-Based Signatures Reveal Vaccine and Checkpoint Inhibitor Responses

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Cancer Immunol Res. 2026 Jan 12. doi: 10.1158/2326-6066.CIR-25-1126. Online ahead of print. ABSTRACT Combination vaccine and checkpoint inhibitor therapy has previously demonstrated immunologic responses in patients with pancreatic ductal adenocarcinoma (PDAC), although with limited efficacy. An urgent need to augment responses has warranted a deeper understanding of how each treatment modality contributes to the overall … Read more

A randomized phase II study: CRS207/GVAX plus anti-PD1 and anti-CTLA4 recruits mesothelin- and mKRAS-specific T cells into PDAC

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Cancer Immunol Res. 2026 Jan 12. doi: 10.1158/2326-6066.CIR-25-0545. Online ahead of print. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal and has poor immunogenicity, warranting the use of vaccines to guide and recruit the immune response. Building on prior efforts to achieve clinical immunotherapeutic responses against PDAC, we conducted a phase II study (NCT03190265) that … Read more

Training Tomorrow’s Leaders in Cancer Immunology

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Cancer Immunol Res. 2026 Jan 12:OF1-OF8. doi: 10.1158/2326-6066.CIR-25-1479. Online ahead of print. ABSTRACT The transition from trainee to independent investigator is one of the most challenging and formative phases of a scientific career. It requires not only scientific expertise but also the skills to lead, mentor, manage, and communicate effectively. The Arthur and Sandra Irving … Read more

Integrated human and mouse single-cell profiling reveals immune-stromal niche driving silicosis. Christina Begka

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Mucosal Immunol. 2026 Jan 9:S1933-0219(26)00003-6. doi: 10.1016/j.mucimm.2026.01.003. Online ahead of print. ABSTRACT Silicosis is an inflammation-driven pulmonary fibrosis caused by occupational inhalation of silica particles. Macrophages are crucial in silicosis pathology, yet their interaction with stromal cells in orchestrating fibrosis progression remains poorly understood. Single-cell RNA sequencing (scRNAseq) of whole-lung lavages from silicosis patients identified … Read more

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{“value”:”Helena L. Crowell, Laura Llaó‐Cid, Gerard Frigola, Samuel Gunz, Irene Ruano, Patricia Lorden, Max Ruiz, Marta Kulis, José Ignacio Martin‐Subero, Holger Heyn, Elias Campo, Anna Pascual‐Reguant”}]]

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Picture-book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single-molecule imaging (SMI) of whole-tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide—at the level of single cells, cellular neighborhoods, and anatomical units such as germinal centers and epithelial substructures. ABSTRACT The … Read more

A throwback on 25 years in pannexin research

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Curr Opin Immunol. 2026 Jan 9;99:102718. doi: 10.1016/j.coi.2025.102718. Online ahead of print. ABSTRACT Cellular channels consisting of pannexins facilitate signaling between the intracellular and extracellular environment. In this respect, pannexin channel opening serves as a pivotal trigger for both inflammatory processes and cell death. While pannexin channels also contribute to normal physiological functions, their roles … Read more

The role of stromal cell immunobiology in understanding and managing Sjögren’s disease

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Curr Opin Immunol. 2026 Jan 9;99:102714. doi: 10.1016/j.coi.2025.102714. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic, heterogeneous autoimmune disorder, clinically dominated by dryness symptoms resulting from inflammatory infiltration of exocrine glands. To date, no validated and resolutive therapeutic strategies are available. Stromal cells are increasingly recognized as critical players in SjD pathogenesis. … Read more

Metabolomic signaling in sarcoidosis pathogenesis

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Curr Opin Immunol. 2026 Jan 9;99:102715. doi: 10.1016/j.coi.2025.102715. Online ahead of print. ABSTRACT Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating granulomas in various organs, predominantly affecting the lungs and lymphatic system. Although the etiology of sarcoidosis remains unknown, it is believed to result from an abnormal immune response triggered by environmental agents in … Read more

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma. Rod A Rahimi

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Mucosal Immunol. 2026 Jan 8:S1933-0219(26)00001-2. doi: 10.1016/j.mucimm.2026.01.001. Online ahead of print. ABSTRACT T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previous studies have examined T cells from the lungs captured via bronchoalveolar lavage (BAL), endobronchial brushings, or biopsies. However, whether … Read more

Biodegradable microparticles promote anti-inflammatory innate immune memory though a size- and mTOR dependent process​Roisin I Lynch on 10 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 10:qiag005. doi: 10.1093/jleuko/qiag005. Online ahead of print. ABSTRACT Emerging evidence demonstrates that innate immune cells can maintain a non-specific memory, not only in response to microbe-associated ligands such as β-glucan, but also synthetic biomaterials and nano- and microparticles. This creates an opportunity to leverage biomaterials which can establish favourable innate … Read more

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