inmunoadmin

J Immunol. 2026 Aug 29;215(9):vkag259. doi: 10.1093/jimmun/vkag259. ABSTRACT Humans produce 12 distinct interferon alpha (IFN-α) subtypes that were previously thought to be functionally redundant. Recent studies have revealed that IFN-α subtypes differ in their ability to control different viral infections. However, little is known about how IFN-α subtypes differentially modulate immune cells to mediate these … Read more

J Immunol. 2026 Aug 29;215(9):vkag251. doi: 10.1093/jimmun/vkag251. ABSTRACT Inflammatory responses require precise posttranscriptional control of gene expression, yet the contribution of circular RNAs (circRNAs) to this process remains poorly understood. Here, we performed circRNA sequencing in murine macrophages stimulated with lipopolysaccharide (LPS) and identified dynamic and stimulus-dependent changes in circRNA expression. Among 1,298 high-confidence circRNAs, … Read more

J Immunol. 2026 Aug 29;215(9):vkag256. doi: 10.1093/jimmun/vkag256. ABSTRACT The expression, localization, and secretion of certain chromatin proteins are tightly regulated in response to inflammatory challenges or tissue damage. High mobility group (HMG) nucleosome-binding proteins can translocate out of the nucleus to act as alarmins in immune cell communications. The consequences of nuclear depletion of HMGs … Read more

J Immunol. 2026 Aug 29;215(9):vkag254. doi: 10.1093/jimmun/vkag254. ABSTRACT Obesity is a risk factor for severe respiratory viral infections, but its impact on bacterial respiratory diseases remains unclear and is sometimes paradoxical. Herein, we demonstrate that diet-induced obese, male C57BL/6J mice exhibited increased resistance to pulmonary infection with Francisella tularensis and Bordetella pertussis compared with lean … Read more