inmunoadmin Curr Opin Immunol. 2026 Feb 27;99:102744. doi: 10.1016/j.coi.2026.102744. Online ahead of print. ABSTRACT The reemergence of the mpox virus (MPXV) as a global health threat, with >100 000 cases reported across 115 countries since the WHO’s 2022 alert, has intensified research into its pathophysiology. MPXV exists in two main clades with distinct geographic and clinical … Read more
Curr Opin Immunol. 2026 Feb 27;99:102742. doi: 10.1016/j.coi.2026.102742. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is a highly heterogeneous chronic systemic inflammatory disease. Approximately 30-40% of patients exhibit an inadequate response to currently available biologic agents and Janus kinase inhibitors. In recent years, rapid advances in multi-omics technologies, including genomics, temporal transcriptomics, proteomics, metabolomics, … Read more
Curr Opin Immunol. 2026 Feb 27;99:102746. doi: 10.1016/j.coi.2026.102746. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Psoriatic arthritis (PsA) is a multidomain inflammatory disease where no instrument captures the full spectrum of activity or its impact on patients’ lives. Accurate outcome measurement is essential for research and personalized care. This review summarizes advances in PsA … Read more
Trends Immunol. 2026 Feb 27:S1471-4906(26)00002-5. doi: 10.1016/j.it.2026.01.002. Online ahead of print. ABSTRACT Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation … Read more
J Leukoc Biol. 2026 Feb 27:qiag025. doi: 10.1093/jleuko/qiag025. Online ahead of print. ABSTRACT Besides their largely specific and abundant toxic granule proteins, their Charcot-Leyden crystals, DNA traps, and the release of leukotrienes, human eosinophils are often seen as affecting the immune response and tissue remodeling due to the release of numerous types of cytokines and … Read more
J Leukoc Biol. 2026 Feb 28:qiag029. doi: 10.1093/jleuko/qiag029. Online ahead of print. NO ABSTRACT PMID:41761660 | DOI:10.1093/jleuko/qiag029
J Clin Immunol. 2026 Feb 28. doi: 10.1007/s10875-026-01985-4. Online ahead of print. NO ABSTRACT PMID:41762359 | DOI:10.1007/s10875-026-01985-4
Trends Immunol. 2026 Feb 26:S1471-4906(26)00010-4. doi: 10.1016/j.it.2026.01.007. Online ahead of print. ABSTRACT Lactation is increasingly recognized as an immune-regulated process. Immune cells shape mammary gland development, coordinate tissue remodeling, and aid in milk production with lasting consequences for maternal health. Here, we summarize recent advances on the roles and dynamics of T cells in the … Read more
J Immunol. 2026 Feb 9;215(2):vkaf346. doi: 10.1093/jimmun/vkaf346. ABSTRACT MR1 is an major histocompatibility complex class I-like molecule that presents small molecule metabolites to MR1-restricted T cells that include a major population of highly conserved T cells known as mucosal-associated invariant T (MAIT) cells. MAIT cells recognize bacterial riboflavin pathway-derived neoantigens and are being attributed an … Read more
J Leukoc Biol. 2026 Feb 27:qiag028. doi: 10.1093/jleuko/qiag028. Online ahead of print. ABSTRACT NF-κB inducing kinase (NIK), an upstream regulator of the noncanonical NF-κB signaling pathway, is implicated in the development of Hypereosinophilic-like syndrome (HES) in mice. HES in human patients is defined by 1.5×109 cells/L circulating in the blood with end-organ infiltration and resultant … Read more
