inmunoadmin

Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections

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J Immunol. 2025 Jul 26:vkaf144. doi: 10.1093/jimmun/vkaf144. Online ahead of print. ABSTRACT Infection with influenza virus remains a significant global health concern due to its ability to acquire mutations at key antigenic sites to escape antibody recognition. While germinal center (GC) and memory B cells have been well studied following influenza infection, the clonal dynamics … Read more

Machine Learning Reassessment of Serum Immune Factors Shows No Unique Immune Profiles Linked to Disease Outcomes in SARS‐CoV‐2‐infected Patients at Hospital Admittance. [[{“value”:”Stefania Rossi, Imerio Capone, Enrico Cabri, Anna Giabelli, Ilaria Rossoni, Giulia Romagnoli, Stefano M. Santini, Cinzia Marcantonio, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna R. Ciccaglione, Federica Frasca, Alessandra d’Auria, Ginevra Bugani, Gabriella d’Ettorre, Guido Antonelli, Carolina Scagnolari, Maddalena Fratelli, Lucia Gabriele”}]]

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Machine learning analysis of serum immune factors clustered SARS-CoV-2 patients into moderate (balanced-immune-modulation [BIM]) and severe groups; the latter composed of two distinct and opposite immune patterns (down-immune-modulation [DIM] and up-immune-modulation [UIM]). DIM/UIM and BIM clusters show different clinical, laboratory and immune parameters including T and B lymphocytes. ABSTRACT The complex pathophysiology of severe acute … Read more

Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions

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J Clin Immunol. 2025 Jul 25;45(1):116. doi: 10.1007/s10875-025-01908-9. ABSTRACT BACKGROUND: The CD247 chain of the T-cell receptor (TCR) is essential for normal T cell development and function. Reported CD247-deficient patients showed severe immunodeficiency despite the presence of two populations of peripheral T cells, most with low TCR levels carrying the germline variant and a few … Read more

Reassessing Polysaccharide Responsiveness: Unveiling Limitations of Current Guidelines and Introducing the Polysaccharide Responsiveness Percentile Approach

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J Clin Immunol. 2025 Jul 25;45(1):115. doi: 10.1007/s10875-025-01915-w. ABSTRACT BACKGROUND: The assessment of polysaccharide responsiveness via vaccination is pivotal in the evaluation of patients for primary immunodeficiency. However, the applicability of current guidelines provided by the American Academy of Allergy, Asthma & Immunology (AAAAI) has been subject to scrutiny. METHODS: We conducted a prospective study … Read more

Ex Vivo Modeling and Pharmacological Modulation of Tissue Immune Responses in Inflammatory Bowel Disease Using Precision‐Cut Intestinal Slices. [[{“value”:”Klaudia Maria Grieger, Valerie Schröder, Susann Dehmel, Vanessa Neuhaus, Dirk Schaudien, Maximillian Fuchs, Helena Linge, Alexander Wagner, Ulf Kulik, Benjamin Gundert, Heiko Aselmann, Armin Braun, Christina Hesse, Katherina Sewald”}]]

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Studying local immune responses in IBD remains challenging. This study demonstrates that precision-cut intestinal slices from IBD patients mimic key immunopathological features ex vivo and respond specifically to immune stimuli. This model allows direct pharmacological modulation of patient tissue ex vivo and offers a powerful platform for translational research. ABSTRACT Inflammatory bowel disease (IBD) affects … Read more

LAG3 Marks Activated but Hyporesponsive NK Cells. [[{“value”:”Valeria Vasilyeva, Olivia Makinson, Cynthia Chan, Maria Park, Colin O’Dwyer, Ayad Ali, Abrar Ul Haq Khan, Christiano Tanese de Souza, Mohamed S. Hasim, Sara Asif, Reem Kurdieh, John Abou‐Hamad, Edward Yakubovich, Jonathan Hodgins, Paul Al Haddad, Giuseppe Pietropaolo, Julija Mazej, Hobin Seo, Qiutong Huang, Sarah Nersesian, Damien Chay, Nicolas Jacquelot, David Cook, Seung‐Hwan Lee, Giuseppe Sciumè, Stephen Waggoner, Michele Ardolino, Marie Marotel”}]]

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NK cells quickly upregulate LAG3 upon activation. LAG3+ NK cells present hallmarks of immune exhaustion. The role of LAG3 in imposing NK cell dysfunction remains to be elucidated. ABSTRACT NK cells are critical for immunosurveillance, yet become dysfunctional when chronically stimulated by virally infected or cancerous cells. This phenomenon is similar to T cell exhaustion … Read more

Platelet‐Based Nanotechnology Improves Cancer Immunotherapy. [[{“value”:”Yanlin Lv, Guanghui Ma”}]]

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This review examines platelet-based nanotechnology in cancer immunotherapy, leveraging platelets’ innate properties via membrane-mimicking systems and engineered platelets to enhance targeting, immune responses, and efficacy, while outlining future directions for its applications in cancer treatment. ABSTRACT Cancer immunotherapy is a cornerstone of precision medicine, yet its efficacy is often hampered by the immunosuppressive and heterogeneous … Read more

Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?. Alexandra Cassano

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Trends Immunol. 2025 Jul 23:S1471-4906(25)00168-1. doi: 10.1016/j.it.2025.07.001. Online ahead of print. ABSTRACT CD4 T cell tolerance is essential for immune homeostasis but its mechanisms remain unclear. Although regulatory T cells (Tregs) mediate T cell-extrinsic tolerance, this review emphasizes the CD4 T cell-intrinsic pathways – anergy and exhaustion – that are triggered by suboptimal or persistent … Read more

Dynamics of virus-specific CD8+ T cells in the human nasal cavity. Joey Ming Er Lim

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Mucosal Immunol. 2025 Jul 22:S1933-0219(25)00078-9. doi: 10.1016/j.mucimm.2025.07.007. Online ahead of print. ABSTRACT The nasal cavity is the entry site for respiratory viruses. Understanding how the nasal cavity sustains memory CD8+ T cell is essential for improving respiratory virus management and vaccine development. Here, we sampled CD8+ T cells from the upper nasal turbinate and peripheral … Read more

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