inmunoadmin

Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury. Sarah Berger

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00105-9. doi: 10.1016/j.mucimm.2025.10.003. Online ahead of print. ABSTRACT Acute lung injury is a common complication of pneumonia, with disease severity linked to inflammatory cell recruitment and lung barrier dysfunction. In this study, we investigate the role of neutrophil-chemoattractant CXCL5 in lung barrier function and inflammation. We examined CXCL5 in patients with … Read more

Viral destruction of the olfactory mucosa elicits immune residence, bone metaplasia, and long-term smell loss. Skye Y Tracey

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00104-7. doi: 10.1016/j.mucimm.2025.10.002. Online ahead of print. ABSTRACT The upper airway is comprised of two distinct mucosal surface tissues, the respiratory mucosa (RM) and the olfactory mucosa (OM), both of which are constantly being exposed to airborne pathogens. The olfactory mucosa is responsible for detecting and conveying odorant information into the … Read more

Epididymitis promotes formation of tertiary lymphoid organs in the cauda epididymidis. Hiba Hasan

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Mucosal Immunol. 2025 Oct 9:S1933-0219(25)00103-5. doi: 10.1016/j.mucimm.2025.10.001. Online ahead of print. ABSTRACT Uropathogenic Escherichia coli is a common pathogen that affects the cauda epididymidis, causing interstitial edema, epithelial damage, leukocyte infiltration, and fibrosis. Despite antibiotic treatment, up to 20 % of patients develop abscesses in the cauda epididymidis, and 40 % experience low sperm counts. … Read more

The epidermal immune microenvironment plays a central role in the pathogenesis of psoriasis

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Curr Opin Immunol. 2025 Oct 9;97:102674. doi: 10.1016/j.coi.2025.102674. Online ahead of print. ABSTRACT Psoriasis is a chronic immune-mediated skin disease whose inflammation can affect other systems and lead to various comorbidities. As a model inflammatory skin disease, while advances in mechanistic insights and targeted therapies have improved outcomes, unmet clinical needs persist. Modern technologies like … Read more

CD8+ lymphocytes in immunity against tuberculosis

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J Immunol. 2025 Oct 10:vkaf268. doi: 10.1093/jimmun/vkaf268. Online ahead of print. ABSTRACT Tuberculosis (TB) is a major global health threat. Deep knowledge of the immune responses against Mycobacterium tuberculosis (Mtb) is crucial for developing effective interventions. Data support that both innate and adaptive CD8+ lymphocytes contribute to protective immunity in Mtb infections, commonly attributed to … Read more

Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity

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Curr Opin Immunol. 2025 Oct 9;97:102677. doi: 10.1016/j.coi.2025.102677. Online ahead of print. ABSTRACT A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are a prime example – respiratory viruses present a threat to their target cells, the epithelial cells that line the airways, but excessive leukocyte … Read more

p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation

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J Immunol. 2025 Oct 10:vkaf214. doi: 10.1093/jimmun/vkaf214. Online ahead of print. ABSTRACT Memory CD8+ T cells are essential for long-term protective immunity. Here, we show that activation of p38 MAPK during the primary response of CD8+ T cells orchestrates a delicate balance between the formation of short-lived effector cells and memory precursor effector cells. p38αfl/flp38βfl/flGzmBcre/- … Read more

NLRC4 deficiency improves host protection during sepsis by regulating macrophage and T-cell responses

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J Immunol. 2025 Oct 10:vkaf272. doi: 10.1093/jimmun/vkaf272. Online ahead of print. ABSTRACT Sepsis followed by multiple organ failure is a leading cause of death in noncoronary intensive care units. While the NLRC4 inflammasome has been shown to play a crucial role in the innate immune response, the role of NLRC4 in sepsis remains unclear. Here, … Read more

CircNR3C1 Promotes Acute Lymphoblastic Leukemia Progression via the MSI2/ENO1/RPS3 Axis​Ping Lei on 10 de October de 2025 at 10:00

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J Leukoc Biol. 2025 Oct 10:qiaf139. doi: 10.1093/jleuko/qiaf139. Online ahead of print. ABSTRACT Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the uncontrolled proliferation of immature lymphoid cells, but the role of circNR3C1 in ALL is not fully elucidated. In this study, expression levels of circNR3C1, RPS3, ENO1, and MSI2 were assessed in … Read more

TEAMwork: Interplay of Post‐Transcriptional Mechanisms, Epigenetics and Metabolism in (Auto‐)Immunity. [[{“value”:”Francesca Rossi, Martin Turner”}]]

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This review discusses the principles underlying the interplay of epigenetics, metabolism, and post-transcriptional regulation of gene expression mediated by RNA-binding proteins, both in the nucleus and in the cytoplasm. Particularly, it focuses on the relevance that these circuits have in lymphocytes and autoimmunity. ABSTRACT Changes in transcript abundance and isoforms, mediated by epigenetic and post-transcriptional … Read more

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