inmunoadmin

IL-21 boosts T cell-therapy efficacy for solid tumors by enhancing mitochondrial Ca2+-mediated motility of effector CD8+ T cells

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Cancer Immunol Res. 2026 Sep 21. doi: 10.1158/2326-6066.CIR-26-0401. Online ahead of print. ABSTRACT Cell motility, characterized by random walk and exploratory search movement, enables effector CD8+ T cells to search for sparse antigen-specific cancer targets within a tumor. This is of special relevance for treatment of solid cancers with adoptive T-cell receptor (TCR) T-cell therapy, … Read more

Towards personalized treatment in juvenile idiopathic arthritis: moving beyond the trial-and-error strategy

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Curr Opin Immunol. 2026 Sep 19;103:102840. doi: 10.1016/j.coi.2026.102840. Online ahead of print. ABSTRACT The progressive elucidation of juvenile idiopathic arthritis (JIA) pathogenesis has led to growing interest in biomarkers to support diagnosis, subset classification, detection of subclinical inflammation, and/or prediction of disease course and therapeutic response (theragnostic biomarkers). JIA management in clinical practice currently follows … Read more

Mitochondrial Phosphatase PGAM5 Negatively Regulates the Induction of Anti-inflammatory Macrophages​Young Jun Kang on 19 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 19:qiag127. doi: 10.1093/jleuko/qiag127. Online ahead of print. ABSTRACT Macrophage polarization toward anti-inflammatory phenotypes is essential for the resolution of inflammation and restoration of tissue homeostasis, yet the mitochondrial mechanisms governing this process remain poorly defined. This study identifies a novel role for the mitochondrial membrane protein, phosphoglycerate mutase 5 (PGAM5), … Read more

A gavage-fomite based method to generate mouse models with natural microbiota

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J Immunol. 2026 Aug 29;215(9):vkag242. doi: 10.1093/jimmun/vkag242. ABSTRACT Laboratory-raised specific pathogen-free (SPF) mice have been indispensable for fundamental immunology research, yet their reliability in predicting human clinical outcomes has been questionable. A major factor contributing to this disconnect is the sanitized housing environment, which deprives laboratory mice of physiological microbial exposure critical for immune maturation. … Read more

Advancing evidence generation in pediatric rheumatology beyond traditional randomized clinical trials: the potential of innovative designs

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Curr Opin Immunol. 2026 Sep 18;103:102841. doi: 10.1016/j.coi.2026.102841. Online ahead of print. ABSTRACT Over recent years, innovative trial methodologies have been increasingly developed to address important limitations of conventional randomized controlled trials, which may require large sample sizes, entail prolonged development timelines, and offer limited flexibility to incorporate emerging evidence as a study progresses. Master … Read more

Loss of kallikrein 5 expression exacerbates allergic skin inflammation including impairing filaggrin processing, promoting Th2 differentiation and inducing dysbiosis. Andrea M Klingler

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Mucosal Immunol. 2026 Sep 18:100404. doi: 10.1016/j.mucimm.2026.100404. Online ahead of print. ABSTRACT Atopic dermatitis (AD) is a chronic allergic skin disease with T helper 2 (Th2) cell predominance and epithelial barrier impairment. The serine protease kallikrein (KLK) 5 has an essential role in regulating keratinocyte desquamation and skin renewal. Increased expression and activity of KLK5 … Read more

Microbiota-derived tryptophan metabolites shape Th2 lymphocyte responses via the aryl hydrocarbon receptor and metabolic reprogramming. Lu Yao

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Mucosal Immunol. 2026 Sep 18:100405. doi: 10.1016/j.mucimm.2026.100405. Online ahead of print. ABSTRACT Allergic diseases are linked with changes in gut microbiota composition and metabolism, but the direct mechanisms linking microbial metabolism to T helper 2 (Th2) lymphocyte differentiation are still poorly understood. Colonization of gnotobiotic animals with Bifidobacterium longum and Clostridium sporogenes resulted in high … Read more

Histone H3K18 Lactylation Drives Immunosuppression by Upregulating CD38 in Myeloid-Derived Suppressor Cells in Lung Cancer

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Cancer Immunol Res. 2026 Sep 18. doi: 10.1158/2326-6066.CIR-25-1401. Online ahead of print. ABSTRACT Histone lactylation is an epigenetic modification that connects lactate metabolism with protein function. Our study identified lactate enhances the protein lactylation level not only in Myeloid-derived suppressor cells (MDSCs) of tumor-bearing mice, but also in the tumor tissues of lung cancer patients. … Read more

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