inmunoadmin

DECTIN-1 stalk length determines binding ability, immune response, and survival in a mouse model of coccidioidomycosis

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J Immunol. 2026 May 14;215(5):vkag098. doi: 10.1093/jimmun/vkag098. ABSTRACT Coccidioidomycosis is a leading cause of pneumonia in the endemic area of the Sonora desert and the central valley of California. The causative agent are the fungi Coccidioides immitis and C. posadasii. While most infections ultimately resolve without treatment, some infections spread to the periphery and cause … Read more

The emerging roles of NFIL3 in immunity

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J Immunol. 2026 May 14;215(5):vkag103. doi: 10.1093/jimmun/vkag103. ABSTRACT NFIL3 (E4BP4) is a basic leucine zipper transcription factor best known for its roles in circadian regulation. It functions primarily as a transcriptional repressor through competitive DNA binding and the recruitment of histone-modifying complexes. More recently, NFIL3 has emerged as a critical regulator of immunity. It is … Read more

FcγRIIIb-deficient neutrophils have defects in ROS production, phagocytosis, and actin polymerization following stimulation through FcγRs

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J Immunol. 2026 May 14;215(5):vkag066. doi: 10.1093/jimmun/vkag066. ABSTRACT Neutrophils are crucial to innate immune responses to microbes. The engagement of opsonized pathogens by Fc gamma receptors (FcγRs) on neutrophil surfaces mediates multiple antimicrobial functions, including phagocytosis and the production of reactive oxygen species (ROS). FcγRIIIb (CD16b) is the most abundant FcγR on human neutrophils. This … Read more

A Novel MSN Mutation Impairs CD4+ T cell Differentiation and Drives Autoantibody Production

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J Clin Immunol. 2026 May 22. doi: 10.1007/s10875-026-02034-w. Online ahead of print. ABSTRACT PURPOSE: To report a patient with a novel MSN mutation causing X-linked moesin-associated immunodeficiency (X-MAID) and investigate its pathogenic mechanisms. METHODS: Clinical and immunological data of the patient were collected. Autoantibody levels were measured using antigen microarrays. Whole-exome sequencing was performed to … Read more

New learnings from the molecular pathology of the synovial tissue in rheumatoid arthritis: from pathogenesis to therapeutic targeting toward precision medicine

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Curr Opin Immunol. 2026 May 21;101:102785. doi: 10.1016/j.coi.2026.102785. Online ahead of print. ABSTRACT Despite the success of targeted therapies in rheumatoid arthritis, the lack of predictive biomarkers of response leads to an empirical treatment approach, often delaying effective intervention due to non-response to the initially selected individualized medication regimens in approximately 40% of patients. Cellular … Read more

Synergism of TNF and IFNγ promotes cell death, but TNF drives innate immune-mediated colitis independent of IFNγ

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J Immunol. 2026 May 14;215(5):vkag111. doi: 10.1093/jimmun/vkag111. ABSTRACT The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that occurs spontaneously in the absence of adaptive immunity. … Read more

Help! Male Hormones Dampen CD4+ T-cell Help in Cancer

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Cancer Immunol Res. 2026 May 21:OF1-OF2. doi: 10.1158/2326-6066.CIR-26-0513. Online ahead of print. ABSTRACT Sex differences in antitumor immunity contribute to disparities in cancer outcomes, yet the role of CD4+ T helper cells in this context remains poorly understood. In this issue, Hunt and colleagues show that sex hormones restrain CD4+ T-cell help in males, weakening … Read more

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