inmunoadmin

Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner

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J Immunol. 2026 May 14;215(5):vkag107. doi: 10.1093/jimmun/vkag107. ABSTRACT Both CD4+ and CD8+ T cells play critical roles in the immunopathogenesis of multiple sclerosis (MS). 1C6 T cell receptor transgenic (TcR-Tg) mice on the nonobese diabetic (NOD) background have a MOG[35-55] (myelin oligodendrocyte glycoprotein 35-55)-specific, major histocompatibility complex class II-restricted TcR that selects for both CD4+ … Read more

A multiplexed, systems-based approach for prediction of antibody neutralization breadth for soluble human receptors

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J Immunol. 2026 May 14;215(5):vkag106. doi: 10.1093/jimmun/vkag106. ABSTRACT For endemically circulating viruses, quantifying neutralization capacity of antibodies in a rapid and high-throughput manner is paramount given the ever-evolving targets of neutralization. Moreover, identifying features of an antibody response correlating with neutralization at the multivariate level can inform vaccine boosting strategies and next-generation monoclonal antibody therapies. … Read more

Preconditioning determines engraftment and therapeutic efficacy of anti-CD19 CAR-T cells in murine lupus

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J Immunol. 2026 May 14;215(5):vkag112. doi: 10.1093/jimmun/vkag112. ABSTRACT Anti-CD19 chimeric antigen receptor (CAR) T cells have emerged as a promising therapeutic strategy for autoimmune diseases, including systemic lupus erythematosus. An unresolved question is how immunosuppressive preconditioning regimens influence CAR-T cell engraftment and therapeutic efficacy. In murine models, whole-body irradiation is required for optimal CAR-T cell … Read more

Tuning PI3K: striking the right balance for optimal CD8 T-cell responses

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J Immunol. 2026 May 14;215(5):vkaf296. doi: 10.1093/jimmun/vkaf296. ABSTRACT CD8 cytolytic T cells are key players in fighting viral infections and other intracellular pathogens. In response to signals from the TCR, costimulatory molecules, and cytokines, CD8 T cells differentiate into populations of cytolytic effectors that can efficiently kill infected and tumor cells, as well as memory … Read more

Saliva as a Non-Invasive Diagnostic for Ocular Sarcoidosis​Priya Hegde on 24 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 23:qiag065. doi: 10.1093/jleuko/qiag065. Online ahead of print. ABSTRACT Sarcoidosis (SRS) is a multi-organ granulomatous disorder that predominantly affects the eyes, lungs, and skin. Biopsy, the standard for a definitive SRS diagnosis, is often impractical for ocular sarcoidosis (OSRS) due to the delicate nature of the eye and risks associated with … Read more

Substance abuse and inflammation: consequences beyond the brain. Liu Yang

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Trends Immunol. 2026 May 25:S1471-4906(26)00104-3. doi: 10.1016/j.it.2026.04.011. Online ahead of print. ABSTRACT Substance use disorders are traditionally conceptualized as disorders of brain reward circuitry; however, accumulating evidence demonstrates that addictive substances exert profound and persistent effects on central and peripheral immune and inflammatory systems. Opioids, psychostimulants, alcohol, nicotine, cannabinoids, and psychedelics modulate immune signaling across … Read more

Systemic IgE promotes allergic rhinitis by licensing Th2-to-Tfh conversion and local IgE production. Takuya Nakai

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Mucosal Immunol. 2026 May 23:100351. doi: 10.1016/j.mucimm.2026.100351. Online ahead of print. ABSTRACT Although systemic allergen-specific IgE is an essential biomarker for allergic rhinitis (AR), its mechanistic contribution to symptom development remains unclear. Here, using mouse models, we investigated how systemic antigen-specific IgE influences AR symptoms and local type 2 inflammation. Mice were adoptively sensitized with … Read more

Biochemical and cytokine environment in skeletally immature patients after traumatic knee injuries

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Curr Opin Immunol. 2026 May 23;101:102789. doi: 10.1016/j.coi.2026.102789. Online ahead of print. ABSTRACT Traumatic knee injuries in skeletally immature patients occur in a unique biological context shaped by growth, high tissue turnover, and distinct immune-repair dynamics. Beyond structural damage, acute post-traumatic changes in synovial fluid and cartilage metabolism can set the trajectory toward persistent symptoms … Read more

The multifaceted role of B lymphocytes in type 1 diabetes. Salma Ayman Khalefa

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Semin Immunol. 2026 May 22;82:102034. doi: 10.1016/j.smim.2026.102034. Online ahead of print. ABSTRACT Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlighted the role of islet antigen-reactive B cells as a … Read more

Hardwired and rewired: Tissue macrophages in homeostasis and cancer​Hesham Mohei on 22 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 13;118(5):qiag046. doi: 10.1093/jleuko/qiag046. ABSTRACT Macrophages are highly heterogeneous innate immune cells that populate virtually all tissues, in which they acquire distinct phenotypes and homeostatic functions shaped by their local environment. Although these cells can arise from either embryonic precursors or circulating monocytes, their ultimate identity reflects an interplay between developmentally … Read more

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