Jing-Jing Du – InmunoES

A trivalent gastric cancer antigen conjugated to a diphtheria toxin epitope synergizes with an NKT cell agonist to boost antitumor immunity

24 de September de 2026 by Jing-Jing Du

The gastric cancer-associated antigen MG7-Ag is aberrantly expressed in multiple gastrointestinal malignancies and represents a promising broad-spectrum target for pan-gastrointestinal tumor peptide vaccines; however, its clinical application is hamper…

Rational design of D(+)-biotin-conjugated resorcinol dibenzyl ethers as tumor-targeted PD-L1 inhibitors for precision cancer immunotherapy

3 de September de 2026 by Jing-Jing Du

ObjectivesThis study aims to discover and characterize novel D(+)-biotin-conjugated PD-L1 inhibitors for precision tumor-targeted cancer immunotherapy.MethodsIntegrated strategies, including computer-aided molecular simulation, antiproliferative activi…

Applications of cell penetrating peptide-based drug delivery system in immunotherapy

22 de January de 2025 by Jing-Jing Du

Cell penetrating peptides (CPPs) are usually positive charged peptides and have good cell membrane permeability. Meanwhile, CPPs are facile to synthesize, and can be functionalized to satisfy different demands, such as cyclization, incorporating unnatu…