Treatment of antibody-mediated rejection in heart transplantation: from empirical combination to multi-target precision intervention

Antibody-mediated rejection (AMR) is the primary immunological obstacle limiting long-term survival in heart transplant recipients. Driven by donor-specific antibodies (DSA), AMR damages graft microvasculature through multiple pathways, including compl…

A multimodal biological margin risk index predicts recurrence after neoadjuvant immunochemotherapy in head and neck squamous cell carcinoma

BackgroundConventional classification of surgical margins is inadequate for head and neck squamous cell carcinoma (HNSCC) treated with neoadjuvant immunochemotherapy (NICT), as it fails to capture the complex biological changes in the tumor microenviro…

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