Wei Chen Coronary artery disease (CAD) remains the leading cause of cardiovascular mortality worldwide and shows a strong age-dependence that classical risk-factor models do not fully explain. A growing body of work indicates that aging is closely associated wi…
BackgroundThis study investigated whether peripheral blood expression of linear ubiquitin chain assembly complex (LUBAC) and OTU deubiquitinase with linear linkage specificity (OTULIN) is associated with stroke severity and functional outcome in acute …
BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized the front-line treatment of advanced hepatocellular carcinoma (HCC). However, the comparative efficacy and safety of different ICI-based regimens—and their consistency across etiologic s…
ObjectiveBy integrating whole-genome resequencing (WGR) with longitudinal transcriptomic profiling, this study aimed to unravel the genetic–transcriptional regulatory network underlying thyroid immune-related adverse events (irAEs) in non-small cell lu…
Lung cancer is a refractory malignancy. Although various therapeutic options, including targeted therapies, immune checkpoint inhibitors, and systemic chemotherapy, have significantly improved the prognosis of lung cancer patients, five-year survival r…
IntroductionThe systematic review and network meta-analysis (NMA) consolidate all relevant randomized controlled trials (RCTs) related to initial immunotherapy treatments for advanced esophageal squamous cell carcinoma (ESCC). Our goal is to thoroughly…
