Xiaohan Zhang – InmunoES

Integrated multi-omics analysis reveals shared IFN-γ-associated monocyte signatures in primary Sjögren’s syndrome and Alzheimer’s disease

9 de September de 2026 by Xiaohan Zhang

BackgroundPrimary Sjögren’s syndrome (pSS) is epidemiologically associated with an increased risk of Alzheimer’s disease (AD); however, the shared IFN-γ-related immune mechanisms underlying this association remain poorly understood.MethodsPeripheral bl…

Mitochondrial metabolic dysfunction drives PANoptosis in retinal pigment epithelium during fungal endophthalmitis: emerging roles of the MITF–FBXW7 axis

13 de April de 2026 by Xiaohan Zhang

Fungal endophthalmitis (FE), although less common than bacterial endophthalmitis, carries a disproportionately high risk of irreversible blindness. Clinical observations show that some patients continue to experience progressive visual loss even after …

GlyT1 inhibition by ALX-5407 attenuates allograft rejection through suppression of Th1 cell differentiation

23 de September de 2025 by Xiaohan Zhang

ObjectiveTransplant rejection driven by Th1 cell-mediated immune responses remains a critical challenge. This study aimed to investigate the role of glycine transporter 1 (GlyT1/SLC6A9) in Th1 differentiation and evaluate the therapeutic potential of i…