Ying Yang – InmunoES

The efficacy and safety of pembrolizumab in the treatment of HER2-negative advanced gastric or gastroesophageal junction cancer: a systematic review and meta-analysis of emerging clinical data

19 de August de 2026 by Ying Yang

IntroductionPembrolizumab, an immune checkpoint inhibitor (ICI) targeting programmed cell death protein 1 (PD-1), has demonstrated significant clinical value in the treatment of human epidermal growth factor receptor 2 (HER2)-negative advanced gastric …

The mechanism of PKM2/HIF-1α axis polarizing TAMs by upregulating glucose-serine metabolism to promote melanoma progression

31 de March de 2026 by Ying Yang

BackgroundMelanoma is the most aggressive skin cancer. Tumor-associated macrophages (TAMs) promote melanoma progression through polarization, however, whether glucose-serine metabolism regulates TAMs polarization and the specific regulatory mechanism r…