Integrative multi-omics dissection identifies ACO2, KLF5, and IMP4 as central regulators of the mitochondrial–immune axis in ulcerative colitis

BackgroundUlcerative colitis (UC) is a chronic relapsing inflammatory bowel disease characterized by persistent mucosal inflammation and epithelial barrier disruption. Emerging evidence suggests that metabolic reprogramming plays a pivotal role in regu…

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