PD-1 blockade combined with anlotinib and bicalutamide for metastatic primary cutaneous apocrine carcinoma: a case report and literature review

BackgroundPrimary cutaneous apocrine carcinoma (PCAC) is a rare malignant adnexal tumor with substantial diagnostic complexity and no established systemic therapy standard for advanced disease.Evidence for endocrine therapy, targeted therapy, and immun…

T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions

Epstein-Barr virus (EBV)-infected B cells effectively induce T cell-mediated immune surveillance that suppresses the proliferation of EBV+ B cells and development of lymphomas. However, it remains unclear whether EBV-specific T cells are involved in th…

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