BackgroundTumor necrosis factor-α (TNF-α) inhibitors such as infliximab are widely used in autoimmune disorders. Paradoxical inflammatory reactions including systemic sarcoidosis and neurosarcoidosis are increasingly recognized but remain rare.Case pre…
BackgroundHepatocellular carcinoma (HCC) patients with bone metastasis-induced paraplegia have an extremely poor prognosis. The potential for neurological recovery following immunotherapy and subsequent rehabilitation in this population remains unclear…
BackgroundBrainstem metastasis from small-cell lung cancer (SCLC) is exceedingly rare and is associated with a dismal prognosis. This study presents a case of brainstem metastasis from SCLC treated with the TMEp-CI-M platform, achieving no evidence of …
ObjectiveThis study aimed to investigate the clinical features, differential treatment responses, and management strategies of encephalitis associated with anti-Kelch-like protein 11 (KLHL11) antibodies.MethodsWe report two cases of anti-KLHL11 encepha…
Guillain-Barré syndrome (GBS) is an immune-mediated acute inflammatory peripheral neuropathy. While it is well-established that its typical manifestations involve the peripheral nerves, it is noteworthy that involvement of the central nervous system an…
Anti-glomerular basement membrane (anti-GBM) disease during pregnancy is rare and often life-threatening. We report a G4P1 woman who developed atypical anti-GBM disease at 13 weeks of gestation. Serial kidney biopsies demonstrated a reduction in active…
Congenital neutropenia refers to a group of rare inherited disorders in which neutrophil development or release is disrupted, predisposing affected children to frequent infections. Among the genes involved, CXCR2 loss-of-function variants have recently…
BackgroundEosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus with symptoms of esophageal dysfunction. It is strongly associated with other atopic conditions in patients and has therefore been recognized as a late manifest…
Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor involving lymph nodes and extranodal sites, classified into conventional and inflammatory pseudotumor (IPT)-like variants. The IPT-like variant predominantly involves the liver and sple…
Diffuse large B-cell lymphoma (DLBCL) frequently involves extranodal sites; however, extensive skull destruction and suspected central nervous system (CNS) involvement associated with a scalp lesion are extremely rare. A 70-year-old man presented with …
