BackgroundThe simultaneous occurrence of severe atopic dermatitis (AD), vitiligo, and alopecia areata (AA) in a single patient is exceptionally rare and poses a significant therapeutic challenge, as conventional “disease-specific” therapies often yield…
Neuroendocrine breast cancer (NEBC) is an exceedingly rare malignant tumor, with primary triple-negative NEBC representing an even rarer and more aggressive subtype lacking standardized treatment guidelines. Although pembrolizumab combined with chemoth…
SAPHO syndrome is a rare autoinflammatory disorder with osteoarticular and cutaneous involvement. Paradoxical skin lesions have been reported during treatment with tumor necrosis factor-α (TNF-α) inhibitors. We describe a 42-year-old man with a 6-year …
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory syndrome most commonly triggered by infection, autoimmune disease, or malignancy. Multiple myeloma (MM)-associated HLH is rare. We report a 70-year-old female who present…
Background and purposeWe describe the clinical characteristics and the therapeutic effect of tocilizumab with Febrile Infection-Related Epilepsy Syndrome (FIRES). FIRES is characterized by super refractory status epilepticus (SRSE) in previously health…
Immune-related cystitis is an uncommon immune-related adverse event (irAE) linked to immune checkpoint inhibitors (ICIs), and managing cases refractory to corticosteroids remains clinically challenging due to the lack of standardized treatment guidelin…
BackgroundWhile immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, neurological immune-related adverse events (n-irAEs) associated with these agents are increasingly recognized. However, kelch-like protein-11(KLHL11)-IgG cerebellit…
IntroductionCytokeratin−positive interstitial reticulum cell (CIRC) tumor, a subtype of fibroblastic reticular cell tumor (FRCT), is an extremely rare primary neoplasm of lymph nodes and soft tissue, with limited understanding of its clinicopathologica…
SAPHO syndrome is a rare autoimmune disorder, and the occurrence of renal involvement in this condition is even more uncommon. We report the case of a 43-year-old male patient with SAPHO syndrome, who initially presented with palmoplantar pustulosis an…
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic autoinflammatory disease characterized primarily by cutaneous manifestations and osteoarticular involvement, and remains challenging to treat. Its pathogenesis i…
