Immune checkpoint blockade (ICB) therapy has dramatically improved the survival outcomes of patients with locally advanced unresectable and metastatic non-small cell lung cancer (NSCLC). In particular, accumulated clinical trials and systematic reviews…
Papillon–Lefèvre syndrome is a rare inherited disorder classically associated with palmoplantar keratoderma and early severe periodontitis, but its clinical presentation may be broader than expected. We report four molecularly confirmed cases from two …
BackgroundSystemic inflammatory manifestations caused by hematologic malignancies may be very similar to autoimmune diseases, making diagnosis difficult. Acute monocytic leukemia (AML-M5) is characterized by significant cytokine production and, in rare…
BackgroundPrimary cutaneous apocrine carcinoma (PCAC) is a rare malignant adnexal tumor with substantial diagnostic complexity and no established systemic therapy standard for advanced disease.Evidence for endocrine therapy, targeted therapy, and immun…
After severe depletion of CD4 T cells in AIDS patients, they are not only prone to a first-time Nocardia infection, but also, even if cured, unable to form protective immune memory, leaving them susceptible to reinfection with the same pathogen. More s…
EGFR exon 20 insertion (ex20ins) NSCLC typically shows limited response to immunotherapy. We report a rare case of a smoker with metastatic EGFR ex20ins (p.S768_D770dup) and high PD-L1 expression (TPS 50%) who achieved exceptional survival (OS = 63 mon…
BackgroundMelioidosis, caused by Burkholderia pseudomallei, is a potentially fatal infection endemic to Southeast Asia and northern Australia. Disseminated disease with bacteremia and multifocal organ involvement carries high mortality, particularly am…
BackgroundChronic mercury exposure may be a potential risk factor for anti-LGI1/Caspr2 autoimmune encephalitis (AE). The effect of chelation therapy on coexisting AE is unknown.MethodsWe report three patients from West China Fourth Hospital, Sichuan Un…
BackgroundThe UNC13D gene encodes Munc13-4, a critical regulator of cytotoxic granule exocytosis in lymphocytes and the protein responsible for familial hemophagocytic lymphohistiocytosis (FHL). As an essential mediator of perforin release from cytotox…
The coexistence of stiff person syndrome (SPS) and myasthenia gravis (MG) is exceptionally rare, with fewer than 20 cases reported to date. Thymoma has been identified in a substantial proportion of these patients, suggesting a potential shared autoimm…
