N-Myc and STAT interactor (NMI), initially identified as a Myc- and STAT-associated protein, is increasingly recognized as a regulatory node in innate antiviral immunity. Current evidence indicates that NMI does not exert a fixed antiviral or proviral …
Post−COVID condition is a heterogeneous, multi−system sequela of SARS−CoV−2 infection that imposes substantial socioeconomic burden and currently needs validated diagnostic biomarkers or established therapeutic pathways. This brief communication synthe…
Gynecological malignancies are characterized by profound cellular heterogeneity, dynamic immune remodeling, and frequent therapeutic resistance, which together limit durable clinical responses. Single-cell sequencing has emerged as a powerful approach …
Extracellular vesicles are shifting the paradigm in vaccine development by virtue of their diverse benefits as carriers of immunogens to targeted hosts. These nano-sized naturally occurring biomolecules offer safety, transmissibility across membranes, …
The gastrointestinal tract, a vital immune organ in the human body, serves as the primary site of direct contact with external antigens. Maintaining immune tolerance is essential for preventing the onset and progression of digestive system diseases. Au…
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules generated by back-splicing events of precursor mRNAs, characterized by superior structural stability, strict tissue specificity, and diverse regulatory functions. Ferroptosis …
Non-small cell lung cancer (NSCLC) represents the majority of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Early-stage NSCLC is primarily treated with surgical resection; however, high recurrence and metastasis r…
Following the global outbreak of the COVID-19 pandemic, the interactions between SARS-CoV-2 and host cells have attracted widespread attention. As crucial intracellular enzymes, E3 ubiquitin ligases are involved in numerous physiological processes, inc…
Novel foods (NF), defined as foods not commonly consumed in Europe before May 1997, represent a growing area of interest in the pursuit of sustainable and nutritionally valuable diets. Before introduction to the market, however, their safety needs to b…
Osteosarcoma remains a major treatment challenge, especially for patients with recurrent, refractory or metastatic diseases. Adoptive cell therapy (ACT), including CAR-T cells, TCR engineered T cells, CAR-NK cells and macrophage based cell therapy, pro…
