Premature ovarian insufficiency (POI) is increasingly recognized as a disorder shaped not only by follicle-intrinsic defects but also by disruption of the ovarian tissue microenvironment. This Mini Review reframes POI as a process of inflammatory ovari…
Welding fumes are widely recognized occupational aerosols, yet their effects on respiratory immune pathways remain incompletely integrated into exposure-oriented assessment. Generated by welding materials, process parameters, surface conditions, and ve…
Colorectal cancer liver metastasis is the most frequent and clinically important pattern of distant spread in colorectal cancer and remains a major determinant of poor prognosis and treatment failure. In the era of immunotherapy, liver metastasis has e…
Persistent inflammation, immunosuppression, and catabolism syndrome (PICS) has emerged as an important contributor to long-term morbidity among survivors of sepsis. This syndrome is characterized by sustained immune dysregulation, metabolic disturbance…
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide. The tumor microenvironment (TME) is a highly immunosuppressive niche shaped by aberrant angiogenesis, chronic inflammation, and extracellular matrix remodelin…
BackgroundHepatitis C virus (HCV)-associated B-cell non-Hodgkin lymphomas represent a compelling model of virus-driven oncogenesis in which immune evasion and viral persistence sustain chronic antigenic stimulation, B-cell clonal expansion and progress…
Esophageal cancer is a highly aggressive malignancy with a notoriously poor prognosis. While immunotherapy, particularly immune checkpoint blockade (ICB), has revolutionized oncology, its clinical efficacy in esophageal cancer is severely limited by pr…
Neonatal neutrophils are often described as immature effector cells with limited marrow reserves and reduced antimicrobial capacity. This account is clinically useful but incomplete: individual functions mature at different rates, neutrophil population…
Osteoarthritis (OA) is a whole-joint disease in which mechanical exposure and low-grade sterile inflammation interact, but their coexistence does not by itself explain why a normally adaptive response becomes self-sustaining. This Mini Review therefore…
Circadian rhythms, an endogenous timing system that enables organisms to adapt to Earth’s rotation, profoundly regulate fundamental physiological processes including cellular metabolism, hormone secretion, and immune surveillance. Recent advances have …
