BackgroundX-linked Hyper-IgM Syndrome (X-HIGM) is a primary immunodeficiency caused by pathogenic variants in CD40L. Loss of functional CD40 ligand interferes with T-cell–dependent B-cell responses and immunoglobulin class-switch recombination, resulti…
ObjectiveTo assess the efficacy and safety of neoadjuvant RC-48 combined with a PD-1 inhibitor in patients with muscle-invasive bladder cancer (MIBC), and to investigate the stratification utility of HER2 expression and tumor-associated tertiary lympho…
BackgroundAdoptive T-cell and natural killer (NK)-cell therapies are expanding across solid tumors, but their registered development in gynecologic malignancies remains difficult to interpret because many studies use basket designs and registry records…
ObjectiveSAPHO syndrome is a rare autoinflammatory/autoimmune overlap disorder whose thymic imaging characteristics remain unexplored. This study evaluated thymic CT attenuation scores in patients with SAPHO syndrome compared with rheumatoid arthritis …
IntroductionRecent advances in regenerative medicine advanced therapies (RMAT) are revolutionizing health care by providing curative treatments for previously untreatable diseases. Flow cytometry assays have been used to measure critical quality attrib…
BackgroundInflammation and insulin resistance are important contributors to asthma pathogenesis. However, the association between the C-reactive protein–triglyceride glucose index (CTI), reflecting both systemic inflammation and insulin resistance, and…
ObjectiveAxial spondyloarthritis (axSpA) is a chronic inflammatory autoimmune disease associated with persistent systemic inflammation and endothelial dysfunction. Angiogenic T cells (Tang cells), defined as CD3+CD31+CD184+ T cells, are specialized imm…
BackgroundType 1 diabetes (T1D) clusters within families, yet shared genetic susceptibility does not fully explain discordance among relatives. We investigated whether single CpG methylation differences recur independently across multiplex T1D families…
ObjectivesIdentifying immune features that distinguish asymptomatic autoantibody-positive at-risk individuals from patients with established autoimmune disease is key to understanding the evolution from autoreactivity to established autoimmune disease….
IntroductionMyositis-specific autoantibodies (MSAs) are clinically important biomarkers that help classify idiopathic inflammatory myopathies and guide clinical management, but reliable detection remains challenging. Immunoprecipitation (IP) is widely …
