BackgroundPolyostotic fibrous dysplasia (POFD) is a mosaic skeletal disorder driven by somatic GNAS mutations that constitutively activate Gsα-cAMP signaling, producing fibro-osseous craniofacial deformities. POFD lesions are histologically classified …
Rosacea is a long-term and relapsing inflammatory skin disorder resulting from dysfunction of the immune and/or neurovascular systems. Paeonol (Pae), the primary active component extracted from Moutan Cortex, exhibits various pharmacological effects, i…
PurposeThis study aimed to evaluate the value of systemic inflammatory prognostic markers and early clinical toxicity in the risk assessment of radiation pneumonitis (RP) after radiotherapy in lung cancer patients. We developed and validated an explain…
BackgroundInflammation-associated epigenetic regulation links microbial exposure and chronic mucosal injury to gastric carcinogenesis, immune remodeling, molecular heterogeneity, and treatment resistance. Previous science-mapping studies have commonly …
IntroductionNeutrophils are increasingly recognized as dynamic regulators of tumor inflammation and immune remodeling. Neutrophil extracellular trap (NET)-related biomarkers have been implicated in cancer progression, but their clinical and immunologic…
BackgroundGastric cancer (GC) is a heterogeneous malignancy that requires improved molecular tools for prognostic stratification. Protein palmitoylation regulates membrane localization and signaling, but the clinical relevance of palmitoylation-related…
BackgroundMajor pathological response (MPR) is a widely used efficacy endpoint for neoadjuvant chemoimmunotherapy (NCIT) in resectable non-small cell lung cancer (NSCLC). However, whether MPR without pathological complete response (pCR) represents a pr…
BackgroundHepatocellular carcinoma (HCC) often coexists with depression, elevating patient mortality by 39%. The tryptophan metabolic axis bridges tumor and neuropsychiatric immune dysfunction, yet the immunometabolic crosstalk underlying HCC-depressio…
ObjectivesTo explore the predictive value of anti-phospholipase A2 receptor (PLA2R) antibody levels and clinical risk factors for relapse in patients with primary membranous nephropathy (pMN) who achieved remission after immunosuppressive therapy.Metho…
BackgroundUlcerative colitis (UC) is a chronic mucosal immune disorder in which 30-50% of patients fail biologic therapy, yet the full-thickness immune architecture of medically refractory disease and reliable tissue-level markers of treatment response…
