BackgroundPrevious evidence demonstrated that neoadjuvant chemo-immunotherapy provides significant prognostic benefits for non-small cell lung cancer (NSCLC). While the efficacy of serplulimab, an anti-PD-1 monoclonal antibody, has been well establishe…
Hematopoietic cell transplantation is a curative therapy for certain hematologic malignancies but is limited in use due to post-transplant complications such as graft-versus-host disease (GVHD), wherein donor cells mount an immune response against host…
BackgroundRubella elimination has substantially reduced virus circulation in China, but the changing pattern of immunity among women entering reproductive age remains unclear. We assessed the contemporary rubella immunity profile among pregnant women i…
ObjectiveTo investigate sphingolipid metabolism for differentiating heat-dampness syndrome from kidney-liver deficiency syndrome in Rheumatoid Arthritis (RA), identify metabolic biomarkers, and integrate transcriptomic data to elucidate molecular mecha…
BackgroundInflammatory bowel disease (IBD) encompasses Crohn’s disease (CD) and ulcerative colitis (UC), two conditions with distinct immunopathological profiles despite shared inflammatory pathways. Comparative mucosal and systemic immune characterisa…
IntroductionHuman leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class I molecule that functions as an immune checkpoint via inhibitory receptors such as immunoglobulin-like transcript 2 (ILT2), immunoglobulin-like tran…
RationaleAntibody recruiters are an innovative class of immunotherapeutics, comprising a tumor-binding module and an antibody-binding module to redirect endogenous antibodies toward target cells. Recruited antibodies can then induce Fc-dependent effect…
The Jianpi Biyan formula (JPBY) is a modern Chinese herbal compound derived from the classic Qing Dynasty formula “Jiegeng Yuanshen Decoction.” It is primarily used to treat allergic rhinitis (AR) with spleen deficiency as the core pathogenesis and has…
The gastric cancer-associated antigen MG7-Ag is aberrantly expressed in multiple gastrointestinal malignancies and represents a promising broad-spectrum target for pan-gastrointestinal tumor peptide vaccines; however, its clinical application is hamper…
BackgroundConsciousness disturbance (CD) is a severe neurological manifestation of cerebral venous sinus thrombosis (CVST), but the association between the systemic immune-inflammation index (SII) and CD has not been fully characterised.MethodsThis ret…
