IntroductionNaturally produced melatonin acts as an antioxidant and immunomodulator, regulating sleep and vital functions. Synthetic melatonin is widely used as a sleep aid by the general population, including U.S. military personnel. Immunomodulatory …
BackgroundAcute myeloid leukemia (AML) is a hematological malignancy with a high incidence of febrile neutropenia during the first two treatment cycles. This study aims to develop a gene signature related to neutrophil extracellular traps (NETs) to enh…
BackgroundCancer-associated fibroblasts (CAFs) play a critical role in hepatocellular carcinoma (HCC) progression. This study aimed to develop a CAF-based risk signature model for predicting prognosis and identifying potential therapeutic targets.Metho…
IntroductionHepatocellular carcinoma (HCC) remains a major global health challenge, characterised by limited therapeutic options and high mortality rates. Despite significant progress in systemic and immune-based therapies, many patients develop resist…
BackgroundAcute myeloid leukemia (AML) is a hematological malignancy with a high incidence of febrile neutropenia during the first two treatment cycles. This study aims to develop a gene signature related to neutrophil extracellular traps (NETs) to enh…
BackgroundMalaria remains a major public health burden, and the development of effective blood-stage vaccines is complicated by extensive antigenic variation in Plasmodium falciparum antigens. PfEBA-175, a leading vaccine candidate, mediates erythrocyt…
BackgroundThe immunosuppressive nature of the HCC tumor microenvironment limits the effectiveness of current immunotherapeutic strategies. Identifying key immune-related regulators is essential for improving patient stratification and therapeutic outco…
BackgroundAcute myeloid leukemia (AML) is a hematological malignancy with a high incidence of febrile neutropenia during the first two treatment cycles. This study aims to develop a gene signature related to neutrophil extracellular traps (NETs) to enh…
BackgroundMalaria remains a major public health burden, and the development of effective blood-stage vaccines is complicated by extensive antigenic variation in Plasmodium falciparum antigens. PfEBA-175, a leading vaccine candidate, mediates erythrocyt…
BackgroundThe immunosuppressive nature of the HCC tumor microenvironment limits the effectiveness of current immunotherapeutic strategies. Identifying key immune-related regulators is essential for improving patient stratification and therapeutic outco…
