European Journal of Immunology

Origin of Hypofunctional CD103+ NK Cells in Cirrhosis‐Associated Ascites. [[{“value”:”Christian Niehaus, Daniel Geanon, Ayesha Lietzau, Marija Jankovic, Christopher Maucourant, Benjamin Maasoumy, Ernesto Sparrelid, Heiner Wedemeyer, Julia Kahlhöfer, Christine S. Falk, Itzel Medina Andrade, Andrea Ponzetta, Niklas K. Björkström, Anke R.M. Kraft, Markus Cornberg, Benedikt Strunz”}]]

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Ascites is one hallmark of decompensated liver cirrhosis. NK cells in cirrhosis-associated ascites are a heterogeneous group of cells with altered functionality and CD103 expression identifies a subpopulation that is likely to be induced by cytokines present in the ascites fluid. ABSTRACT The occurrence of ascites is a frequent complication associated with the decompensation of … Read more

Resolution of Autoimmune Uveitis Requires CCL20‐Dependent Regulatory T Cells. [[{“value”:”John Dostal, Kayleigh Peters, Trisha McDonald, Darren J. Lee”}]]

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Resolution of EAU at 90 days after induction is dependent on CCL20. During the resolution of EAU, the emergence of regulatory T cells (post-EAU Tregs) in the spleen that suppress EAU is dependent on CCL20. However, post-EAU Tregs do not require CCL20 to suppress EAU. ABSTRACT Uveitis is a leading cause of blindness worldwide and … Read more

Identification and Mapping of Human Lymph Node Stromal Cell Subsets by Combining Single‐Cell RNA Sequencing with Spatial Transcriptomics. [[{“value”:”Cristoforo Grasso, Janna E. G. Roet, Catarina Gago de Graça, Johanna F. Semmelink, Michael de Kok, Ester Remmerswaal, Aldo Jongejan, Perry D. Moerland, Reina E. Mebius, Lisa G. M. van Baarsen”}]]

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Single-cell RNA sequencing of enzymatically dissociated human lymph node stromal cells (LNSCs) reveals transcriptional and spatial heterogeneity. Following cell sorting and phenotyping, stromal subsets were validated across multiple datasets, mapped within lymph node architecture, and analyzed for subset-specific immune interactions, enabling a comprehensive reconstruction of the LNSC landscape and its role in lymph node organization … Read more

Comparative Analysis of the TCR Repertoire in Bone Marrow CD8+ T Cells From Patients With Acute Myeloid Leukemia, Myelodysplastic Neoplasms, and Chronic Myelomonocytic Leukemia. [[{“value”:”Kyriaki Katsiki, Athanasios Tasis, Anastasia Filia, Ioannis Kotsianidis, Ioannis Mitroulis”}]]

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Bone marrow CD8+ T cells from patients with MDS and CMML show decreased TCR diversity compared to AML. Treatment with the hypomethylating agent azacitidine in MDS and CMML alters TCR repertoire of CD8+ T cells without affecting TCR diversity.

mTOR Modulates NLRP3 Inflammasome Activation via Nuclear Translocation and STAT1 Inhibition. [[{“value”:”Alvaro González‐Dominguez, Shuling Zhang, Daniel Boy‐Ruiz, Daniel Connors, Raquel de la Varga‐Martínez, Beverly A. Mock, Mario D. Cordero”}]]

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mTOR is binding to NLRP3 until a NLRP3-inflammasome stimulus. After activation, mTOR is translocated to the nucleus to inhibit STAT1 and support the NLRP3 inflammasome assembly and activation. mTOR inhibition with rapamycin reduces mTOR presence in the nucleus and increases STAT1 which represses NLRP3 inhibiting the activation. ABSTRACT The NLRP3 inflammasome has emerged as an … Read more

Butyrate Selectively Targets Super‐Enhancers and Transcriptional Networks Associated with Human Mast Cell Function. [[{“value”:”Jelle Folkerts, Marjolein J. W. de Bruijn, Wilfred F. J. van IJcken, Rudi W. Hendriks, Ralph Stadhouders”}]]

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Butyrate, a short-chain fatty acid (SCFA) derived from dietary fibers, selectively inhibits human mast cell activation by targeting transcription start sites (TSS) and super-enhancers regulating key mast cell genes. Local histone hypoacetylation induced by butyrate likely drives transcriptional suppression and reduced degranulation, providing new insights into how SCFA modulates inflammation. ABSTRACT Mast cells are key … Read more

Cover Story: Eur. J. Immunol. 6’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

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