Recent evidence supports a model in which the pool of adult immune cells is actually composed of cells derived from fetal, neonatal, and adult waves of hematopoiesis. In this review, we discuss this evidence in the context of innate lymphoid cells (ILC), with a focus on the environmental signals required for their development during early … Read more
Our study shows that mature B cells expressing IgD exhibit significantly higher sensitivity to glucocorticoid (GC)-induced cell death. This elevated sensitivity is specifically dependent on GC receptor (GR) expression and is accompanied by enhanced activation as well as terminal differentiation of B cells. Our findings elucidate how exogenous GCs affect B cell survival and suggest … Read more
The tissue metabolic environment in autoimmunity influences immune and nonimmune cells via fuelling cellular metabolism or through metabolic signalling. Intracellular metabolic sensors combine several environmental cues to control transcription, metabolism, and cell function. The function of each cell contributes to the concerted dysfunctional behaviour of a tissue in autoimmunity. ABSTRACT Autoimmunity causes damage to organs … Read more
This review examines the failure of peripheral immune tolerance as the initiating factor in rheumatoid arthritis (RA), focusing on the role of dendritic cells. It discusses strategies to convert these cells from immunogenic to tolerogenic states, while also exploring emerging research on the anatomical sites where this critical loss of tolerance occurs. ABSTRACT Rheumatoid arthritis … Read more
We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.
Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double-negative thymocyte proliferation and T-cell production. ABSTRACT Family of Sequence Similarity 83H (FAM83H/SACK1H) is primarily expressed in epithelial cells, where it interacts with casein … Read more
The MHC-E peptide binding methods described here—nano-differential scanning fluorimetry and fluorescence polarisation—demonstrate shared peptide binding repertoires with subtle binding hierarchy differences for the tested HLA-E and Mamu-E allotypes. When combined, these methods illustrate how minor MHC-E-peptide thermal stability changes equate to significant binding strength differences. ABSTRACT The primary function of MHC-E—human leukocyte antigen (HLA)-E in … Read more
European Journal of Immunology, Volume 56, Issue 1, January 2026.
The increased lactate secretion by B cells from people with obesity and aging is a stimulus for pathogenic autoimmune anti-dsDNA antibodies. The effects of lactate are mediated by phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and inhibited by a neutralizing antibody that blocks the lactate transporter SLC5A12, responsible for lactate uptake and activation … Read more
Picture-book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single-molecule imaging (SMI) of whole-tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide—at the level of single cells, cellular neighborhoods, and anatomical units such as germinal centers and epithelial substructures. ABSTRACT The … Read more
