European Journal of Immunology

Inhibition of Melanoma Growth by Ex Vivo Expanded Tumor‐Specific CD8+ T Cells Is Dependent on the Configuration of Nanoscale Artificial APCs. [[{“value”:”Antara Mondal, Faisal Jamal, Arpita Das, Arnab Kumar Sahoo, Khushboo Chaudhary, Sarmili Chowdhury, Aakriti Jha, Santiswarup Singha”}]]

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A critical configuration of nanoscale a-APCs displaying high valency of tumor-specific peptide-MHCs and co-stimulatory molecules is essential for expanding antigen-specific CD8+ T-cells ex vivo at high yield with profound production of cytolytic molecules, resulting in enhanced therapeutic potential for inhibiting the growth of solid tumors. ABSTRACT Adoptive T-cell therapy is an emerging immunotherapeutic strategy for … Read more

The Inactive X Chromosome: A Genetic Driver of Female‐Biased Rheumatic Autoimmune Disorders?. [[{“value”:”Léa Ferrayé, Mélissa Nieucel, Magali Savignac, Julie Chaumeil, Jean‐Charles Guéry”}]]

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Recent works indicate that several X-linked genetic mechanisms contribute to the female predisposition for autoimmune diseases. Here, we review the recent findings that underscore the significance of the alteration of X chromosome inactivation (XCI) maintenance and the putative role of the long noncoding XIST/Xist RNA in this process but also as a sex-biased source of … Read more

Advances in Regulatory Cell Therapy for Type 1 Diabetes: Emerging Strategies and Future Directions. [[{“value”:”Laura Passerini, Aurora Forlani, Silvia Gregori”}]]

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Regulatory cell-based therapies, encompassing stem-like cells, T regulatory cells, and tolerogenic dendritic cells, have already been tested in clinical trials for reversing autoimmunity in type 1 diabetes. These early successes opened new perspectives for next-generation antigen-specific strategies to achieve durable and self-sustaining immune tolerance. ABSTRACT Type 1 diabetes (T1D) is an autoimmune disorder characterized by … Read more

RSV‐Induced Regulation of DC via H3K4 Demethylase KDM5b. [[{“value”:”Mohamed M. Mire, Llilian A. Martinez, Ashley M. Cortes, Susan Morris, Andrew Rasky, Catherine Ptaschinski, Nicholas W. Lukacs”}]]

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Summary of findings showing proposed effects of RSV-induced Kdm5b in the DC resulting in the exasperated lung pathology seen with RSV related to modified type 1 responses. ABSTRACT We previously observed an upregulation of Kdm5b, an H3K4 demethylase, following RSV infection of DCs that regulates key innate cytokines, including Type I IFN and TNF. As … Read more

Adaptive NKG2C+ NK cells in cytomegalovirus seropositive individuals predominantly lack NKR‐P1A receptor expression. [[{“value”:”Mohamad Basem Alkassab, Fareeha Ajmal Shaikh, Caroline Hamm, Mir Munir A. Rahim”}]]

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Expansion of the adaptive NKG2C+ NK cells during cytomegalovirus (CMV) infection is restricted to the subset lacking NKR-P1A receptor. This is associated with increased proliferation of NKR-P1A‒, but not NKR-P1A+, NK cells in CMV-infected individuals. ABSTRACT The impact of cytomegalovirus (CMV) infection in shaping natural killer (NK) cell receptor (NKR) repertoire highlights the importance of … Read more

Passive Immunization in the Prevention and Treatment of Viral Infections. [[{“value”:”Romila Moirangthem, Yotam Bar‐On”}]]

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The development of new technologies for generating monoclonal antibodies has made it possible to extend the use of monoclonal antibodies for controlling viral infections. Here, we discuss the advances in antibody cloning techniques and the current use of passive immunization both as a preventative measure and treatment of viral infection. ABSTRACT The basic concepts of … Read more

Mutations in RNU4ATAC Are Associated With Chilblain‐Like Lesions and Enhanced Type I Interferon Signalling. [[{“value”:”Nic Robertson, Aakash Joshi, Francesca Ritchie, Ina Schim van der Loeff, David Royan, Angela L. Duker, Gillian I. Rice, Michael B. Bober, Sahar Mansour, David I. Campbell, Mary Brennan, Lindsay Brown, Laura Jones, Eleri Williams, Andrew P. Jackson, Yanick J. Crow”}]]

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Mutations in the non-coding RNA gene RNU4ATAC are associated with growth restriction and complications related to antibody deficiency. Here, we report that innate immune dysfunction is a previously unrecognised feature of this disorder. In particular, painful chilblain-like lesions are common in RNU4ATAC patients and are linked to dysregulated type I interferon signalling.

Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans. [[{“value”:”Leslie Naesens, Steven Callens, Tessa Kerre, Simon J. Tavernier, Filomeen Haerynck”}]]

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This review highlights how genetic mutations impairing antiviral signaling pathways increase susceptibility to viral infections. The findings emphasize the importance of genetic screening and personalized treatment strategies to manage infectious risks and tailor vaccine protocols for genetically susceptible individuals. ABSTRACT The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and … Read more

Linking Epitope‐Specific T‐Cell Receptors to IFNγ Secretion Using Nanovial Technology. [[{“value”:”Jet van den Dijssel, Tejas Menon, Hayley A. McQuilten, Oliver Eltherington, Alexis Gonzalez, Sevana Baghdasarian, Citradewi Soemardy, Dino Di Carlo, Klaas P.J.M. van Gisbergen, Anja ten Brinke, Carolien E. van de Sandt”}]]

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To link IFNγ-secretion levels of epitope-specific T-cells with their TCRαβ, we coated nanovials with pHLA-I to capture and activate epitope-specific T-cells and their secreted IFNγ, followed by index-sorting and TCRαβ sequencing. We demonstrate that nanovials are a promising tool to link single epitope-specific TCRαβ clonotypes to the cell’s functional properties.

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