Correction to “Immunological Impact of Oncolytic Adenoviruses on Cancer Therapy: Clinical Insights”.
European Journal of Immunology, Volume 56, Issue 1, January 2026.
European Journal of Immunology
SARS‐CoV‐2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{“value”:”Lisan H. Kuijper, Laura Y. L. Kummer, Laura Fernandez Blanco, Karlijn van der Straten, Mathieu A. F. Claireaux, Amélie V. Bos, Miranda C. Dieker‐Meijer, Tineke Jorritsma, Mariël C. Duurland, Maurice Steenhuis, Juan J. Garcia Vallejo, Koos P. J. van Dam, Eileen W. Stalman, Luuk Wieske, Sander W. Tas, Laura Boekel, Gert‐Jan Wolbink, Theo Rispens, Taco W. Kuijpers, Filip Eftimov, Marit J. van Gils, Anja ten Brinke, S. Marieke van Ham, T2B! immunity against SARS‐CoV‐2 study group”}]]
SARS-CoV-2 mRNA vaccination triggers bystander activation of B cells, transiently increasing antibody levels after the first vaccination against influenza, RSV, and tetanus. Reactivation of B cell responses also occurred, where (CD11c+) MBC and DN3 are expanded after SARS-CoV-2 mRNA vaccination, independent of antigen exposure. ABSTRACT After antigen encounter, long-lived antibody-secreting cells (ASC) secrete high-affinity circulating … Read more
Issue Information: Eur. J. Immunol. 1’26.
European Journal of Immunology, Volume 56, Issue 1, January 2026.
Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{“value”:”Megan M. Hanlon, Ursula Fearon, Ellen M. Gravallese”}]]
Synovial tissue macrophages are essential coordinators of joint homeostasis and inflammatory responses in rheumatoid arthritis. Here, we highlight recent advances that have enabled a deeper characterization of synovial tissue macrophages and their distinct phenotypes and functions in health and disease. ABSTRACT Synovial tissue macrophages are critical orchestrators in the pathogenesis of rheumatoid arthritis, comprising a … Read more
Cover Story: Eur. J. Immunol. 1’26.
Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more
Thrombospondin‐1 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells. Karl‐Gösta Sundqvist
The C-terminal of TSP-1 senses cell contact, which triggers N-terminal cleavage by urokinase, adhesion, and cytoplasmic spreading in T cells and platelets. In contrast, full-length TSP-1 induces the development of polar cell shape and migration in T cells 2D and 3D; polar cell shape 2D, independent of its receptor LRP1, and polar cell shape 3D … Read more
Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [[{“value”:”Thorge Dobbertin, Lucas Schirmer”}]]
This review summarizes emerging spatially resolved multi-omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche-specific immunopathology that shape cellular reactivity and vulnerability. ABSTRACT Spatial omics technologies enable high-resolution mapping of transcriptomic, proteomic, and metabolic profiles within intact tissues, revealing how immune, stromal, and parenchymal … Read more
Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse. [[{“value”:”Izumi Ohigashi, Hitomi Kyuma, Eri Otsu, Shinichi Hayashi, Tatsuya Takemoto, Yousuke Takahama”}]]
CCR7-mediated chemokine signaling regulates the medullary migration of thymocytes to establish self-tolerance. By comparing the thymic phenotype of Ccl21b-KO mice with that of Ccl21a-KO mice, we show that Ccl21a plays a predominant role compared with Ccl21b among CCR7 ligands in the thymus. ABSTRACT Self-tolerance in T cells is a vital self-defense strategy for mammals to … Read more
CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein‐Coupled Receptors. [[{“value”:”Javier Fernández‐Calles, Daniela Kužílková, Fanny Hedin, Violeta Bakardjieva‐Mihaylova, Karolina Škvárová Kramarzová, Menno C. van Zelm, Antonio Cosma, Tomas Kalina, Pablo Engel, the Human Cell Differentiation Molecules (HCDM) organization”}]]
HLDA Workshops were established 40 years ago to develop a standardized CD molecule nomenclature for leukocyte cell-surface molecules by comparing monoclonal antibodies (mAbs) produced by different laboratories and companies. The HLDA11 Workshop focused on validating G-protein-coupled receptors (GPCRs) targeting mAbs and assessing cell-type-specific expression patterns in leukocytes. ABSTRACT Monoclonal antibodies (mAbs) targeting cell-surface molecules are … Read more
Serous Cavity Mast Cells Depend on the ROQUIN Paralogs. [[{“value”:”Klaus Heger, Ali Masjedi, Assa Yeroslaviz, Theodor Zeng, Seren Baygün, Angela Vicente‐Luque, Chia‐I. Lien, Lena Osswald, Dieter Saur, Daniel Kovacs, Marc Schmidt‐Supprian”}]]
The RNA-binding ROQUIN paralogs are critical immune regulators. We demonstrate that mast cell-specific deficiency for ROQUIN-1 and ROQUIN-2 in mice leads to loss of mast cells in serous cavities. ROQUIN-1 and 2 ablation does not affect mast cell degranulation or proinflammatory cytokine secretion, although they regulate many mRNAs directly or indirectly. ABSTRACT Mast cells are … Read more