European Journal of Immunology

Dimethyl Fumarate Negatively Regulates MYC Signaling and Promotes Cell‐Cycle Arrest in T‐Cells through a GSH‐Dependent Mechanism. [[{“value”:”Kazuya Sato, Shin‐ichiro Kawaguchi, Junko Izawa, Takashi Ikeda, Kiyomi Mashima, Norihito Takayama, Hiroko Hayakawa, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda”}]]

by

Dimethyl fumarate (DMF) inhibits T-cell proliferation and induces apoptosis by depleting glutathione (GSH) and accumulating reactive oxygen species (ROS). Here, we show that DMF-induced oxidative stress disrupts multiple cell-signaling pathways, including MYC, leading to cell cycle arrest and impaired proliferative responses in activated T-cells. ABSTRACT Recent evidence indicates that the TCA cycle metabolite fumarate plays … Read more

Human IL‐6‐Producing B Cells Promote the Differentiation of Monocytes Toward an Anti‐Inflammatory CD16⁺CD163⁺CD206⁺PD‐L1⁺ Phenotype in Tuberculosis. [[{“value”:”Alan Bénard, Luciana Balboa, Maxime Caouaille, Lea Ravon‐Katossky, Etienne Meunier, Simon Fillatreau, Maria Del Carmen Sasiain, Olivier Neyrolles, Denis Hudrisier”}]]

by

The supernatant of M. tuberculosis-stimulated B cells promotes monocyte polarization toward an anti-inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ phenotype via an IL-6/STAT3 pathway. Confirmed with B cells from TB patients, this pathway impairs monocyte proinflammatory functions and may contribute to immune suppression in tuberculosis. Created in BioRender. Neyrolles, O. (2025) https://BioRender.com/930ras3 ABSTRACT The polarization of the monocyte/macrophage compartment toward an … Read more

Investigating Polyreactivity of CD4+ T Cells to the Intestinal Microbiota. [[{“value”:”Ahmed Saadawi, Florian Mair, Esther Rosenwald, Daniel Hoces, Emma Slack, Manfred Kopf”}]]

by

T-cell recognition of microbiota-derived epitopes is key to immune homeostasis. Here, we used an unbiased screening platform to identify novel immunogenic epitopes from Akkermansia muciniphila and Bacteroides thetaiotaomicron. We demonstrated that these epitopes are conserved across multiple other bacterial strains, suggesting their potential relevance in broader immune interactions. ABSTRACT Antigen-specific recognition of microbiota by T … Read more

Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment. [[{“value”:”Fengxia Gao, Rushil Shah, Gang Xin, Ruoning Wang”}]]

by

Metabolic antagonism in the TME suppresses CD8+ T cell function by depleting essential nutrients and generating toxic byproducts. Metabolic symbiosis between tumor cells and TAMs fosters an immunosuppressive microenvironment. Disrupting metabolic interactions can overcome immune suppression, boost antitumor immunity, and enhance immunotherapy efficacy. ABSTRACT The fate of immune cells is fundamentally linked to their metabolic … Read more

Rapid Detection of Anti‐IFN‐α2 Autoantibodies Using a New Automated VIDAS Assay Prototype. [[{“value”:”Sylvie Pons, Laurence Generenaz, Adrian Gervais, Anne Puel, Paul Bastard, Nathalie Renard, Valerie Guyot, Cecile Vinit, Fei Zheng, Karen Brengel‐Pesce, Kahina Saker, Jean‐Christophe Richard, Alexis Mathian, Zahir Amoura, Karim Dorgham, Guy Gorochov, Jean‐Laurent Casanova, Aurore Fleurie, Sophie Trouillet‐Assant”}]]

by

Autoantibodies neutralizing Type I interferons increase the risk of severe viral diseases and are linked to autoimmune conditions. The automated VIDAS assay is suitable for anti-IFN-α2 IgGs quantification, offering a swift, reliable, user-friendly, single test for clinical management.

CD3xHER2 bsAb‐Mediated Activation of Resting T‐cells at HER2 Positive Tumor Clusters Is Sufficient to Trigger Bystander Eradication of Distant HER2 Negative Clusters Through IFNγ and TNFα. [[{“value”:”Chen‐Yi Liao, Patrick Engelberts, Michiel van Dijk, Annemieke Timmermans, John W. M. Martens, Elsa Neubert, Erik H.J. Danen”}]]

by

Spatiotemporal aspects of bystander killing triggered by bispecific antibodies: (1) Resting T-cells recognize HER2+ tumors via CD3xHER2 bsAbs. (2) Local T-cell activation induces direct HER2+ tumor killing and IFNγ/TNFα release. (3) IFNγ/TNFα mediate paracrine killing of HER2− cells. (4) HER2− cells are eliminated in mixed (A) and distant (B) areas. ABSTRACT Bispecific antibodies (bsAbs) bridging … Read more

CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination. [[{“value”:”Chloé Lescale, Timea Marton, Amaury Vaysse, Guillaume Rode, Estelle Vincendeau, Alice Libri, François Dossin, Ludovic Deriano”}]]

by

Here we show that CST and SHLD are required for CSR, while SHLD1-CTC1 interaction via the SHLD1 LDLP motif is dispensable. Mechanistically, we show that CTC1 and SHLD1 are epistatic during CSR, preventing genetic instability, exacerbated DSB end-resection, and microhomology-mediated end-joining at Igh switching sites. Created in Biorender.com. ABSTRACT Downstream of 53BP1-RIF1 lies the Shieldin … Read more

Modulation of Host Immunity by Microbiome‐Derived Indole‐3‐Propionic Acid and Other Bacterial Metabolites. [[{“value”:”Burkhard Schütz, Felix F. Krause, R. Verena Taudte, Mario M. Zaiss, Maik Luu, Alexander Visekruna”}]]

by

The gut commensal Clostridium sporogenes metabolizes dietary tryptophan into indole-3-propionic acid (IPA). In this review, we highlight recent findings suggesting that IPA acts as an effective signaling molecule, modulating the function of Th17 lymphocytes and resulting in protection against intestinal inflammation. ABSTRACT In recent years, we have witnessed a rapidly growing interest in the intricate … Read more

Interleukin‐8/Matrix Metalloproteinase‐9 Axis Impairs Wound Healing in Type 2 Diabetes through Neutrophil Extracellular Traps‐Fibroblast Crosstalk. [[{“value”:”Dimitrios Tsilingiris, Anastasia‐Maria Natsi, Efstratios Gavriilidis, Christina Antoniadou, Ioanna Eleftheriadou, Ioanna A. Anastasiou, Anastasios Tentolouris, Evangelos Papadimitriou, Evgenios Eftalitsidis, Panagiotis Kolovos, Victoria Tsironidou, Alexandra Giatromanolaki, Maria Koffa, Nikolaos Tentolouris, Panagiotis Skendros, Konstantinos Ritis”}]]

by

Neutrophil extracellular traps (NETs) in type 2 diabetes induce a pro-fibrotic but functionally impaired phenotype in cutaneous fibroblasts, associated with collagen breakdown by NET-bound MMP-9. IL-8 released in NETs promotes its own expression in both neutrophils/fibroblasts and neutrophil MMP-9 production, creating positive feedback loops that hinder wound healing. ABSTRACT Neutrophils interact with and activate fibroblasts … Read more

PLC and PAD2 Regulate Extracellular Calcium‐Triggered Release of Macrophage Extracellular DNA Traps. [[{“value”:”Neha Mishra, Magdalena Mohs, Nico Wittmann, Stefan Gross, Paul R. Thompson, Lukas Bossaller”}]]

by

Extracellular calcium induces MET release from human macrophages. Concurrently, extracellular calcium activates the NLRP3 inflammasome. Citrullinated histones, MMP12, MPO and ASC specks are bound to METs and are released by rupture of the plasma membrane, where they exhibit bactericidal properties. ABSTRACT Macrophages can respond to infection or cellular stress by forming inflammasomes or by releasing … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri