European Journal of Immunology

Induction of Tolerogenic Dendritic Cells by a Noncoding Oligonucleotide. [[{“value”:”Kahkashan Kamal, James Trumbo, Elina Richardsdotter‐Andersson, Marie Wahren‐Herlenius, Anna‐Lena Spetz”}]]

by

In this article, the authors elucidated the immunoregulatory role of an oligonucleotide (ssON) that favors the induction of human tolerogenic dendritic cells (DC). The tolerogenic profile was evidenced by reduced responsiveness to lipopolysaccharides (LPS) (A). Importantly, the tolerogenic DCs had upregulated PD-L1 molecules and functionally inhibited the proliferation of alloreactive T cells and induced FoxP3+ … Read more

Administration of the NOD2 Agonist MDP Reduces Cryptosporidium parvum Infection in Neonatal Mice Through IL‐22 Involvement. [[{“value”:”Mégane Fernandez, Tiffany Pezier, Julien Pichon, Yves Le Vern, Catherine Werts, Sonia Lacroix‐Lamandé”}]]

by

Neonatal mice infected with C. parvum and treated with MDP, a NOD2 agonist, exhibited reduced intestinal infection. This protective effect was mediated by a local immune response involving neutrophil recruitment, IL-22 production, antimicrobial peptide expression, and epithelial regeneration in an IFN-γ-dependent manner. Therefore, MDP administration enhances host defense mechanisms against C. parvum infection in neonatal … Read more

Identification and Functional Validation of Novel Pathogenic Variants in Primary Immunodeficiencies. [[{“value”:”Arvinden VR, Geeta Madathil Govindaraj, Aditya Ramdas Iyer, Sangita Paul, Athulya Edavazhippurath, Abhinav Jain, Pragya Gupta, Gauspasha Yusuf Deshmukh, Shivani Singh, Vinodh Saravanakumar, Juhi Bhardwaj, Srishti Sharma, Tancia P. Benny, Priya Saravanan, Rahul C. Bhoyar, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Harie Vignesh, Bani Jolly, Aparna Dalvi, Umair Ahmed Bargir, Manisha Madkaikar, Binukumar BK, Sridhar Sivasubbu, Sivaprakash Ramalingam, Vinod Scaria”}]]

by

Primary immunodeficiency is a monogenic disorder that affects proper immune functioning. Diagnostic yield of these inherited diseases are burdened by the presence of variants of unknown significance. In this study we functionally validated novel variants associated with immunodeficiency to ascertain its pathogenicity. ABSTRACT Primary immunodeficiency diseases (PIDs) are inherited disorders caused by genetic defects affecting … Read more

LILRA5 Functions to Induce ROS Production on Innate Immune Cells. [[{“value”:”Zuyi Fu, Matevž Rumpret, Irina Kube‐Golovin, Mykola Lyndin, Vera Solntceva, Yuxi Zhao, Anastasia Konieva, Na Liu, Adrian T. Press, Stefanie B. Flohé, Michael Bauer, Gunther Wennemuth, Bernhard B Singer, Alex J. McCarthy”}]]

by

Ligation of the activating LILRA5 receptor specifically stimulates ROS production by monocytes and neutrophils. Though LILRA5 transcripts are upregulated upon immune stimulation, surface LILRA5 expressions are dynamically regulated. Enhanced soluble LILRA5 was observed during immune challenge, suggesting that dynamic regulation of LILRA5 modulates ROS induction and innate immune responses. ABSTRACT Activating immune receptors provides mechanisms … Read more

CD16A Shedding Regulates Innate Cell Engager‐Induced Serial Killing by Natural Killer Cells. [[{“value”:”Chiara Zambarda, Karolin Guldevall, Christian Breunig, Damien Toullec, Patrick A. Sandoz, Valentina Carannante, Shanshan Xu, Patrick Ross, Kyra Kuhnigk, Niklas Sandström, Jacopo Fontana, Susanne Wingert, Sheena Pinto, Julia Knoch, Alamdar Hussain, Arnika K. Wagner, Jens Pahl, Evren Alici, Joachim Koch, Björn Önfelt”}]]

by

NK cells kill tumor targets via antibody-dependent cellular cytotoxicity (ADCC), mediated by the receptor CD16A. We show that the bispecific innate cell engager acimtamig (AFM13) enhances ADCC and boosts NK cell serial killing. Live-cell imaging revealed that CD16A shedding is essential for efficient NK cell detachment and sustained killing. ABSTRACT Natural killer (NK) cells can … Read more

Short‐Chain Fatty Acid Sodium Butyrate Suppresses Protective Humoral Immunity by Inhibiting Follicular T Helper Cell Differentiation. [[{“value”:”Bhushan Nikam, Someshwar Nath Jha, Yatish Thakare, Poonam Coshic, Nimesh Gupta”}]]

by

We show that sodium butyrate suppresses Tfh-cell differentiation, via HDAC inhibition, leading to inefficient germinal center responses and impaired antibody generation. This suboptimal humoral immunity fails to confer protection against virus infection, underscoring sodium butyrate’s potential impact on shaping GC-derived protective immunity. ABSTRACT The gut microbiome and its metabolites are critical regulators of intestinal homeostasis, … Read more

TEAMwork: Interplay of Post‐Transcriptional Mechanisms, Epigenetics and Metabolism in (Auto‐)Immunity. [[{“value”:”Francesca Rossi, Martin Turner”}]]

by

This review discusses the principles underlying the interplay of epigenetics, metabolism, and post-transcriptional regulation of gene expression mediated by RNA-binding proteins, both in the nucleus and in the cytoplasm. Particularly, it focuses on the relevance that these circuits have in lymphocytes and autoimmunity. ABSTRACT Changes in transcript abundance and isoforms, mediated by epigenetic and post-transcriptional … Read more

Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice. [[{“value”:”Camilla Basso, Corinne De Gregorio, Roberta Marzi, Florian Kirchner, Gabor Gyülveszi, Mélanie Migaud, Sinu Paul, Alessandro Sette, Antonio Lanzavecchia, Salomé LeibundGut‐Landmann, Jean‐Laurent Casanova, Anne Puel, Simone Becattini, Federica Sallusto”}]]

by

Th17 cells confer protection against Candida albicans infection. In patients with STAT1 gain-of-function (GOF) mutations and chronic mucocutaneous candidiasis (CMC), Candida-specific Th cell responses are numerically preserved but skewed toward Th1 and Th2. In a mouse model of mucosal vaginal infection, Th1 and Th2 cells fail to control fungal growth, and Th2 cells can even … Read more

Loss of PI3Kδ Activity Drives Autoimmune Colitis by Impairing Extrathymic Treg Differentiation. [[{“value”:”Ee Lyn Lim, Yamin Qian, Fuminori Sugihara, Atsushi Tanaka, Shimon Sakaguchi”}]]

by

Mice with inactivated PI3Kδ develop colitis, reminiscent of immune-related adverse effects observed in human patients treated with PI3Kδ inhibitors. We demonstrate that loss of PI3Kδ activity abrogates the Helios− peripherally induced Treg (pTreg) population in the mouse colon, resulting in inflammation and tissue damage that Helios+ thymic Tregs fail to control. ABSTRACT Peripherally derived regulatory T … Read more

Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages. [[{“value”:”Lynn Mes, Jennifer Veth, Julie Van Coillie, Jim B. D. Keijser, Elise Mantel, Richard van der Mast, Theo Rispens, Gestur Vidarsson, Marjolein van Egmond, Jeroen den Dunnen, Hung‐Jen Chen”}]]

by

Anti-SARS-CoV-2 spike IgA drives inflammation in human macrophages through FcαRI-Syk signaling. IgA2 immune complexes amplify cytokine production and alter glycolysis and mitochondrial function more potently than IgA1, indicating subclass-specific immunometabolic reprogramming. These findings identify IgA2 as a pathogenic factor in severe COVID-19 and highlight pathways with potential therapeutic relevance. ABSTRACT Severe COVID-19 is an immunological … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: OpenSSL SSL_connect: SSL_ERROR_SYSCALL in connection to lkl.dolarkurum.com:443