European Journal of Immunology

• CD4+ and CD8+ tissue-resident memory T (TRMs) cells which are CD103+PD-1+CD25+ICOS+ and, CD4+CD103−PD-1+CXCR5+CCR5+/− T follicular helper/T peripheral helper (Tfh/Tph) cells infiltrate lesional relative to nonlesional skin in atopic dermatitis (AD). • Frequencies of CD4+CD103+PD-1+TRMs, monocyte-derived dendritic cells (Mo-DCs), and inflammatory monocytes positively correlate with disease severity (EASI) within AD lesions. ABSTRACT Atopic dermatitis (AD) … Read more

IL-4, IL-15, and type I IFN coordinately shape the heterogeneity of CD44hi CD49d– VM CD8 T cells. IL-4 acts specifically on Ly6C+ Sca-1− cells, while IL-15 promotes the development of both Ly6C+ Sca-1− and Ly6C− Sca-1− VM subsets. Type I IFN signaling primarily regulates Sca-1+ populations. Functionally, Ly6C+ and/or Sca-1+ subsets exhibit enhanced IFN-γ and … Read more

This review explores the structure and function of meningeal immunity throughout development. It highlights key differences in immune cell composition, lymphatic development, and neuroimmune interactions between neonates and adults, offering insights into neonatal vulnerability to CNS infections and potential avenues for future research. ABSTRACT The central nervous system (CNS) is responsible for controlling the entire … Read more

CD8+ T cells exhibit dual roles at the maternal-fetal interface supporting tolerance via IL-10 and TGF-β and aiding implantation and vascular remodeling through TNF-α and IFN-γ. In HIV infection, CD8+ T cells expand, driving inflammation, PD-L1 upregulation on trophoblasts, and cytotoxic dysfunction via reduced Granzyme B and Perforin, compromising placental immunity. ABSTRACT The global HIV … Read more

Dipeptidyl peptidase 9 (DPP9) inhibition with novel compounds induces lytic cell death in human leukocytes. We report that this cell death occurs via DPP9, inflammasome-activated caspase-1, GSDMD, and GSDME. Additionally, DPP8/9 activity is upregulated in monocyte-to-dendritic cell differentiation and DPP9 localizes both to the cytoplasm and the nucleus in leukocytes. ABSTRACT Dipeptidyl peptidase 9 (DPP9) … Read more

Ascites is one hallmark of decompensated liver cirrhosis. NK cells in cirrhosis-associated ascites are a heterogeneous group of cells with altered functionality and CD103 expression identifies a subpopulation that is likely to be induced by cytokines present in the ascites fluid. ABSTRACT The occurrence of ascites is a frequent complication associated with the decompensation of … Read more

Resolution of EAU at 90 days after induction is dependent on CCL20. During the resolution of EAU, the emergence of regulatory T cells (post-EAU Tregs) in the spleen that suppress EAU is dependent on CCL20. However, post-EAU Tregs do not require CCL20 to suppress EAU. ABSTRACT Uveitis is a leading cause of blindness worldwide and … Read more

Single-cell RNA sequencing of enzymatically dissociated human lymph node stromal cells (LNSCs) reveals transcriptional and spatial heterogeneity. Following cell sorting and phenotyping, stromal subsets were validated across multiple datasets, mapped within lymph node architecture, and analyzed for subset-specific immune interactions, enabling a comprehensive reconstruction of the LNSC landscape and its role in lymph node organization … Read more

European Journal of Immunology, Volume 55, Issue 6, June 2025.

Bone marrow CD8+ T cells from patients with MDS and CMML show decreased TCR diversity compared to AML. Treatment with the hypomethylating agent azacitidine in MDS and CMML alters TCR repertoire of CD8+ T cells without affecting TCR diversity.