• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14+ … Read more

We performed a comprehensive blood phenotyping in 24 kidney-transplanted patients and 10 healthy volunteers. Among numerous immune cell subsets, mainly differences in B-cell populations were highlighted, with an increase of CD11c+ memory B cells in blood from kidney transplanted patients with long-term posttransplantation time. Abstract The use of immunosuppressive treatment is required to prevent rejection … Read more

Neutrophil extracellular traps (NETs) contribute to SLE development, yet their interaction with Regulatory T cells (Tregs) remains obscure. This study reveals that selectively enhanced NETs in mice suppress Treg production and function. Through modulating naive CD4+ T cells via TLR4, NETs inhibit Treg differentiation, bridging innate and adaptive immune responses. ABSTRACT In systemic lupus erythematosus … Read more

Complement activation is a distinct feature of (neuropsychiatric) systemic lupus erythematosus. However, little is known about complement regulation by endogenous soluble complement inhibitors. We show differences in serum levels between (NP)SLE patients and healthy controls, but regulator levels are not discriminative between NPSLE and SLE. Created with Biorender.com. Abstract Systemic lupus erythematosus (SLE) is marked … Read more

Targeting CD28H with a properly selected antibody activates NK cells by increasing their cytotoxicity and overcoming inhibitory signals. ScRNA-seq analysis of ccRCC shows that CD28H+ NK cells infiltrate HHLA2+ tumors and could be effectively targeted by this antibody thus offering a promising approach for enhancing antitumor responses. Abstract Tumor evasion has recently been associated with … Read more

Here, we studied the impact of myeloid cell depletion on atherosclerosis in Apoe − /− mice using a Macrophage Fas-induced apoptosis (MaFIA) mouse model. MaFIA mice carry an inducible apoptosis gene under the control of the Csf1r promotor, enabling specific and transient depletion of Csf1r-expressing cells. Upon systemic induction of apoptosis, plaque macrophage and smooth … Read more

T-cell-derived lymphotoxins promoted IL-17A+ and GM-CSF+ responses at disease onset. At peak EAE, ILC3-derived lymphotoxins inhibited the infiltration of IFN-ɣ- and GM-CSF-producing CD4+ T cells into the CNS, while T-cell-derived lymphotoxins limited Treg accumulation. B-cell-derived lymphotoxins promoted type 1 cytokine production by T cells in rhMOG1–125-induced EAE. Abstract Lymphotoxin α and lymphotoxin β (LTs), TNF … Read more

Immune-adipose-metabolism factors in the macro- and micro-breast-tumour environment are influenced by the magnitude of surgery and certain clinicopathological features. These results provide insight into the complex immune processes of the peri-operative period. Abstract Surgical resection is the primary treatment approach for patients with breast cancer. Despite optimal multimodal treatment, metastatic recurrence remains a risk. Surgery-mediated … Read more

Schematic diagram of ATG16L2-mediated NLRC4 inflammasome activation during Salmonella typhimurium infection. After NAIPs recognize the different components of S. typhimurium, ATG16L2 promotes the binding of NAIPs to NLRC4, enhancing the oligomerisation of ASC and the subsequent caspase-induced cleavage of IL-1β and GSDMD. N-terminal perforates the cell membrane, causing pyroptosis and LDH leakage. Abstract As cytoplasmic … Read more

Dectin-1 is a C-type lectin receptor for the innate sensing of fungi. This receptor exists in two major isoforms in mice differing in a stalk domain, which determines their degradative pathway. Here, we characterise the properties of the two isoforms in a cellular context and using a newly established in vivo model. Abstract Dectin-1 is … Read more