European Journal of Immunology

The development of new technologies for generating monoclonal antibodies has made it possible to extend the use of monoclonal antibodies for controlling viral infections. Here, we discuss the advances in antibody cloning techniques and the current use of passive immunization both as a preventative measure and treatment of viral infection. ABSTRACT The basic concepts of … Read more

Mutations in the non-coding RNA gene RNU4ATAC are associated with growth restriction and complications related to antibody deficiency. Here, we report that innate immune dysfunction is a previously unrecognised feature of this disorder. In particular, painful chilblain-like lesions are common in RNU4ATAC patients and are linked to dysregulated type I interferon signalling.

This review highlights how genetic mutations impairing antiviral signaling pathways increase susceptibility to viral infections. The findings emphasize the importance of genetic screening and personalized treatment strategies to manage infectious risks and tailor vaccine protocols for genetically susceptible individuals. ABSTRACT The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and … Read more

To link IFNγ-secretion levels of epitope-specific T-cells with their TCRαβ, we coated nanovials with pHLA-I to capture and activate epitope-specific T-cells and their secreted IFNγ, followed by index-sorting and TCRαβ sequencing. We demonstrate that nanovials are a promising tool to link single epitope-specific TCRαβ clonotypes to the cell’s functional properties.

European Journal of Immunology, Volume 55, Issue 5, May 2025.

Through the analysis of TCR repertoires, differential gene expression, and flow cytometry, we propose a mechanism in which surface CD69-negative memory T cells reside in the bone marrow of healthy humans. Therefore, we challenge the notion of surface CD69-positive T cells representing the only bona fide resident phenotype in the bone marrow. ABSTRACT Across tissues, … Read more

Human CD8+ and CD4+ memory and regulatory T-cell subsets, but not naïve or effector cells, may become CD69+ bone marrow-resident cells, suggesting that they could be maintained long-term as quiescent cells. CD4+ memory T-cells and EOMES+Tr1-like cells, respectively, expressed IL-7Rα and IL-15Rβ, suggesting that they compete for different homeostatic niches. ABSTRACT Maintenance of memory T-cells … Read more

T follicular helper (TFH) cells provide essential help to B cells in germinal centers (GCs). TFH and GC B cell responses are long-lasting in draining mediastinal lymph nodes of Litomosoides sigmodontis-infected BALB/c mice, a rodent model of filarial infection. ABSTRACT T follicular helper (TFH) cells are the primary CD4+ T helper cell subset providing help … Read more

This review article summarizes the currently available information on the functions of atypical IκB proteins including Bcl-3, IκBNS, and IκBζ, which have been studied mostly in mouse models. We focus on the regulation of these modulators of transcription, describe their role in lymphocyte differentiation, and their involvement in the development of autoimmunity. ABSTRACT Signaling pathways … Read more

Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more