European Journal of Immunology

VSIG4‐Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity. [[{“value”:”Els Lebegge, Daliya Kancheva, Jolien Van Craenenbroeck, Sam Ernst, Pauline M. R. Bardet, Aarushi A. Caro, Máté Kiss, Neema Ahishakiye Jumapili, Romina Mora Barthelmess, Maida Zivalj, Naela Assaf, Leen Ali, Yvon Elkrim, Jesse Demuytere, Jan De Jonge, Geert Raes, Eva Hadadi, Nick Devoogdt, Cécile Vincke, Kiavash Mohavedi, Lars Vereecke, Wim Ceelen, Benoit Stijlemans, Damya Laoui, Sana M. Arnouk, Jo A. Van Ginderachter”}]]

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Although VSIG4+ LPMs and VSIG4− LPMs are identical at the transcriptomic and surface proteomic level, VSIG4+ LPMs are superior phagocytes that protect against CRC peritoneal outgrowth and influence the early phase of T. brucei brucei infection. ABSTRACT Large peritoneal macrophages (LPMs) play a role as gatekeepers of peritoneal homeostasis by providing a first line of … Read more

Itaconate Has Limited Protective Effects in Experimental Malaria Models. [[{“value”:”Fran Prenen, Emilie Pollenus, Hanne Meers, Sofie Knoops, Rebecca Sadler, Margot Deckers, Evanna L. Mills, Philippe E. Van den Steen”}]]

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During Plasmodium infection, inflammatory monocytes upregulate ACOD1, leading to increased production of the anti-inflammatory metabolite itaconate. While ACOD1 deletion has no effect in the lethal PbNK65-E model, it exacerbates disease in the milder PcAS model. These findings highlight a modest but context-dependent protective role for itaconate in malaria. ABSTRACT In severe malaria, dysregulated metabolism and … Read more

Updates on Toll‐Like Receptor 10 Research. [[{“value”:”Federica Riva, Marta Muzio”}]]

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Toll-like receptor 10 (TLR10 or CD290) shares the same structural organization as the other TLRs but shows a unique expression pattern and distinct functional activities yet to be fully elucidated. This review summarizes key steps and recent updates on TLR10 research including open questions and future perspectives. ABSTRACT Toll-like receptors (TLRs) are transmembrane proteins that … Read more

Treg Control of CD80/CD86 Expression Mediates Immune System Homeostasis. [[{“value”:”Yong‐Hee Kim, Abir K. Panda, Ethan M. Shevach”}]]

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The acute depletion of Tregs induces activation of APCs and Tconvs, eventually leading to autoimmune disease. This activation could only be prevented by the blockade of CD80/CD86, so CD80/CD86-CTLA-4 interactions appear to be the most important Treg suppressor mechanism in the maintenance of immune homeostasis in the steady state. ABSTRACT Foxp3+ regulatory T cells (Treg) … Read more

Repeated CD107a Staining Enables Identification of Serial Degranulating NK Cells. [[{“value”:”Jens Niemann, Maren Claus, Vanna Imširović, Carsten Watzl”}]]

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Upon repeated target cell contact serial degranulating NK cells are identified by multiple staining events using differentially labeled anti-CD107a (LAMP1) antibodies. This flow-cytometry-based method allows for the characterization and isolation of serial degranulating NK cells.

Elevated Plasma Levels of NET Components in Men with Severe COVID‐19 Correlates to Increased Amounts of IL‐18. [[{“value”:”Emelie Backman, Remigius Gröning, Alicia Lind, Christoffer Granvik, Hinnerk Eilers, Anna Lange, Clas Ahlm, Sara Cajander, Mattias N. E. Forsell, Johan Normark, Constantin F. Urban”}]]

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Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.

Plasmodium berghei Radiation‐Attenuated Sporozoite‐Immunized Mice Require Infectious Sporozoite Challenge to Maintain Protective Immunity. [[{“value”:”Hardik Patel, Naveen Yadav, Rajesh Parmar, Vishakha Bhurani, Aditi Mathur, Dolly Jagwani, Avantika Ahiya, Dillip K. Behera, Urszula Krzych, Sarat K. Dalai”}]]

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Multiple immunizations of mice with Plasmodium berghei radiation-attenuated sporozoites (Pb RAS) induce durable protective immunity, provided that 1° sporozoite (spz) challenge occurs early or within 10 months following the most recent RAS boost immunization. Delaying 1° challenge results in parasitemia. Pb RAS develops partially into early liver stages, is unable to progress to blood-stage parasites, … Read more

Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation. [[{“value”:”Kunie Obayashi, Tomomitsu Doi, Kazuhiro Sumida, Motoyoshi Endo”}]]

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IgE induces stronger ER stress than IgG1 due to its constant region, particularly the Cε3 domain, which binds BiP more efficiently. Genetic and structural analyses confirmed IgE’s higher BiP-binding capacity. ER stress, driven by IRE1-XBP1 signaling, regulates plasma cell differentiation, suggesting IgE-specific mechanisms in immune responses.

Distinct HLA Haplotypes Are Associated With an Altered Strength of SARS‐CoV‐2‐Specific T‐Cell Responses and Unfavorable Disease Courses. [[{“value”:”C. Dörnte, A. Datsi, V. Traska, J. Kostyra, M. Wagner, O. Brauns, C. Lamsfuß, H. Winkels, V. Balz, J. Enczmann, O. Adams, L. Mueller, H. Baurmann, B. Eiz‐Vesper, A. Bonifacius, R. V. Sorg, C. Dose, J. Schmitz, A. Richter, J. Fischer, M. Schuster”}]]

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Analysis of the T-cell epitope landscape of SARS-CoV-2 suggests T-cell intrinsic factors as likely modulators of disease severity and that the capacity of MHC-peptide presentation remains stable among circulating SARS-CoV-2 viral strains. ABSTRACT Infection with SARS-CoV-2 results in mild to severe COVID-19 disease courses. Several studies showed the association of impaired T-cell responses and certain … Read more

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