European Journal of Immunology

Testosterone suppresses Th17 cell differentiation and alleviates Th17-driven skin inflammation in an experimental psoriasis model. Mechanistically, testosterone binds to the ligand-binding domain (LBD) of RORγt, inhibiting its transcriptional activity required for IL-17 production and other Th17-cell-associated proinflammatory gene expression. These findings provide a mechanistic explanation for testosterone’s immunosuppressive effects and offer insights into the gender … Read more

Blood CD8 T cells in mice with advanced liver fibrosis exhibit IFN-γ and granzyme B hyperfunction, and animal responses to ectopic tumour challenge and immunotherapy are impaired. ABSTRACT Immune dysfunction in liver disease contributes to significant morbidities, depending on liver damage severity and aetiology. We previously reported long-lasting generalized CD8 T cell hyperfunction in chronic … Read more

European Journal of Immunology, Volume 55, Issue 8, August 2025.

• SLAM family receptors regulate the susceptibility of hematopoietic stressed cells to NK cell-mediated cytotoxicity. • Leukemia cells might downregulate the expression of SLAM family receptors to avoid being recognized and lysed by NK cells. • NK cell engagers containing SLAM family receptors may be an important resource for the design of therapeutic strategies aiming … Read more

In N-ERD patients, oral aspirin-induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin-induced bronchoconstriction. ABSTRACT Previous studies confirmed increased group 2 innate lymphoid cell (ILC2s) count in nasal scrapings, alongside a reduced blood … Read more

During filarial nematode infection with Litomosoides sigmodontis, PD-L2 down-regulates Th2 cell expression of GATA-3 and Th2 cytokines and enables parasite survival. Concurrently, B cells suppress protective immunity through a mechanism that does not involve PD-L2. ABSTRACT Filarial nematodes infect over 200 million people, predominantly stimulating a Type 2 immune response. Protective immunity takes decades to … Read more

European Journal of Immunology, Volume 55, Issue 8, August 2025.

Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Using scRNAseq and spatial analysis, we analyse cDC1 states and spatial distribution in tumours during immune-mediated rejection. We identify two cDC1 activation states, each occupying different regions and associated with distinct CD8+ T cell populations. This reveals the spatial organisation of cDC1 states that may be key to anti-tumour immunity. ABSTRACT CD8+ T cells are … Read more

Conditionally replicating oncolytic adenoviruses (OAds) mediate cancer cell destruction while triggering robust immune responses. Clinical data reveal their ability to remodel the tumor microenvironment and enhance responsiveness when combined with other therapies. This review highlights immune-modulating effects of OAds in patients, with a focus on therapeutic implications and combination strategies. ABSTRACT Oncolytic immunotherapy, particularly using … Read more