European Journal of Immunology

Efficient Expression and Purification of Recombinant Mouse Dimeric IgA. [[{“value”:”Antonia Geisse, Tao Zhang, Jonathan Schreiber, Kristina Markova, Sophie Burkhalter, Hedda Wardemann, Andrew J. Macpherson, Tim Rollenske”}]]

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Immunoglobulin (Ig) A is the main antibody isotype found on mucosal surfaces in mammals, where it is predominantly present as a dimer. Here we provide an easy, scalable, efficient, and broadly applicable method to produce and purify monoclonal mouse dimeric IgA from single B cell Ig transcripts to study mucosal antibody responses at single-cell level.

Aberrant Nutrient Metabolism in T Cells: Pathogenesis Insight and Therapeutic Target for Autoimmune Diseases. [[{“value”:”Shumei Cao, Jiao Jiang, Haoyuan Yin, Xiaoyu Su, Qilin Li, Junhui Wu, Wenrui Li, Lai Wang, Qianjin Lu”}]]

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Nutrient metabolism (glucose, amino acids, lipids) serves as a critical fourth signal in T-cell activation, with its dysregulation promoting autoimmune pathogenesis in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis through metabolic reprogramming, offering potential therapeutic targets. ABSTRACT Abnormal T-cell activation and differentiation are pivotal in the pathogenesis of autoimmune disorders. Traditionally, T cell activation … Read more

CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation. [[{“value”:”Nima Yassini, Eva Goljat, Camilla Panetti, Matthias Rath, Nicole Joller”}]]

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The innate actions of the immune system allow for a rapid response to potential threats. Here we show that upon classical T cell activation, both murine and human adaptive immune cells can acquire innate capabilities allowing them to respond to cytokines in a TCR independent manner. ABSTRACT Memory T cells, a sizable compartment of the … Read more

Extracellular Vesicles in Lung Transplantation: Biomarkers, Pathophysiological Players, and Therapeutic Weapons?. [[{“value”:”Valentin Mandin, Amandine Dupuy, Adrien Tissot, Nicolas Degauque, Richard Danger, Hoa Le Mai, Sophie Brouard”}]]

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Extracellular vesicles (EVs) contribute to alloimmune responses and inflammation after lung transplantation through their immunogenic cargo (cytokines, miRNAs, MHC, Col-V, and Ka1T). Potential biomarkers (Col-V, Ka1T, LKB1, and HLA-G) may predict acute rejection and CLAD. EV-based therapies during ex vivo lung perfusion and ischemia-reperfusion preclinical models show potential to improve outcomes. ABSTRACT In the field … Read more

Beyond Negative Regulation: IL‐1R8 and IL‐1R2 as Novel Immune Checkpoints. [[{“value”:”Domenico Supino, Roberto Garuti, Cecilia Garlanda”}]]

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Self-regulation of the IL-1 system mediated by the negative regulatory receptors IL-1R8 and IL-1R2 results in tuning of inflammation and metabolic rewiring, as well as lymphoid or myeloid cell immune suppression. IL-1R8 and IL-1R2 are emerging as potential therapeutic targets to modulate immunopathology and re-educate lymphoid or myeloid cells, respectively. ABSTRACT IL-1 family members and … Read more

Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases. [[{“value”:”Laurens Bogers, Jasper Rip, Suzanne C. Franken, Kirsten L. Kuiper, Ana M. Marques, Annet F. Wierenga‐Wolf, Marie‐José Melief, Cato E. A. Corsten, Romy A. M. Klein Kranenbarg, Janet de Beukelaar, Ide Smets, Beatrijs H. Wokke, Maarten J. Titulaer, Joost Smolders, Marvin M. van Luijn”}]]

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Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4+ T-cell frequencies were a disease-specific feature of MS, while reduced T-bet+ and CXCR3+ B-cell levels were associated with progressive disease.

Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment. [[{“value”:”Nabina Pun, David R. Withers”}]]

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Innate lymphoid cells (ILCs) orchestrate tissue homeostasis and inflammation. Here, we review current understanding of how different subsets of ILCs can contribute to both pro- and anti-tumour immunity depending on the local context. ABSTRACT The innate lymphoid cell (ILC) family includes natural killer (NK) cells, recognised for over 50 years, as well as several more … Read more

Bacterial Vaginosis‐Associated Prevotella timonensis Enhances Dendritic Cell–T Cell Clustering and Subsequent T Cell Proliferation. [[{“value”:”Marleen Y. van Smoorenburg, Julia L. Nerwinska, John L. van Hamme, Ester B. M. Remmerswaal, Celia Segui‐Perez, Karin Strijbis, Teunis B. H. Geijtenbeek”}]]

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Prevotella timonensis, a bacterium present during vaginal dysbiosis, increases cell–cell clustering between primary DCs and CD4 T cells and subsequently enhances CD4 T cell proliferation. These results provide insight into how microbiota directly affect the immunological function of DCs, thereby modulating inflammation. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/t02mfss. ABSTRACT Dysbiosis of the vaginal microbiome … Read more

STING and Nonnecroptotic MLKL‐Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells. [[{“value”:”Trine S. Jensen, Marlene F. Laursen, Lea Schort, Agnieszka J. Banasik, Ralf Agger, Martin R. Jakobsen, Emil Kofod‐Olsen”}]]

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In this study, we show that caspase-8 inhibition induce maturation in DCs through a synergistic crosstalk between the STING signaling pathway and RIPK1-RIPK3-MLKL pathway, without induction of cell death in the DCs. The mature DCs secrete TNF-α that induces cancer cell death in DC/cancer cell co-cultures upon concomitant caspase-8 inhibition. ABSTRACT Activation of the cGAS-STING … Read more

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