European Journal of Immunology

Human T Cell Responses to Flavivirus Vaccines. [[{“value”:”David Wullimann, Hans‐Gustaf Ljunggren”}]]

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This review summarises current knowledge of T cell responses induced by flavivirus vaccines being licensed or under development. Existing vaccines against flaviviruses have been developed and analysed primarily in the context of antibody responses, while the role of T cells in contributing to immunity against flaviviruses is less studied. ABSTRACT Flaviviruses are major human pathogens … Read more

The Streptomyces Metabolite Thiostrepton Inhibits Regulatory T Cell Differentiation and Function to Boost Antitumor Immune Responses. [[{“value”:”Luana Silva, Luís Almeida, Fatima Al‐Naimi, Daniele Carvalho Nascimento, Aleksandra Lopez Krol, Luis Eduardo Alves Damasceno, Hakim Echchannaoui, José Carlos Alves‐Filho, Luciana Berod, Tim Sparwasser”}]]

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Regulatory T cells (Tregs) promote tumor progression and therapy resistance by suppressing antitumor immunity. Here, we identify the antibiotic thiostrepton as a novel Treg-targeting immunomodulator for cancer immunotherapy. Thiostrepton impairs Treg differentiation and suppressive capacity. In an MC38 model, thiostrepton treatment reduced intratumoral Foxp3⁺ Tregs and significantly inhibited tumor growth. ABSTRACT Regulatory T cells (Tregs) … Read more

Booster Injection with Birch Pollen Extract Activates B‐Cellular Memory Responses in Patients Having Completed Allergen Immunotherapy. [[{“value”:”Carolin Baum, Christian Möbs, Wolfgang Pfützner”}]]

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A single booster injection of allergen extract is capable of rapidly activating B-cellular memory several years after completion of allergen immunotherapy, demonstrated by an increase of allergen-specific IgG-producing cells and IgG/IgG4 antibodies as well as improved allergen-blocking capacity. This indicates that booster injections allow maintenance of long-term allergen tolerance. ABSTRACT Allergen immunotherapy (AIT) of patients … Read more

The Mitigating Effect of Combined Glucocorticoids with Immune Checkpoint Inhibitors on Lymphocyte Activation Gene‐3 and Programmed Death‐1 Expression. [[{“value”:”Smadar Gertel, Ari Polachek, Victoria Furer, Tali Ofir Dovrat, Chen Avaky, Adi Broyde, Hila Nochimovitz, Ori Elkayam”}]]

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Mechanism of GCs combined with ICI may induce LAG-3, an inhibitory molecule expression (A) Immune checkpoint inhibitors (ICIs) are a class of drugs that work by blocking inhibitory molecules on immune cells (B) Glucocorticoids (GCs) are used to manage the immune-related adverse events following ICI therapies (C) Concomitant GCs with ICI therapies can induce peripheral … Read more

Neuro‐ILC Interactions in Host Physiology and Defence. [[{“value”:”Cristina Godinho‐Silva, Miguel Rendas, Henrique Veiga‐Fernandes”}]]

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Local and systemic neuroimmune interactions involving innate lymphoid cells (ILCs) shape organismal physiology and defence. Neuro-ILC circuits operate across different organs through brain–body and inter-organ communication axes. These neuroimmune circuits integrate external environmental cues and internal physiological signals to regulate organ physiology, thermogenesis, metabolism, endocrine function, and organismal health. ABSTRACT Over the past decade, innate … Read more

HLA‐DR‐Expressing γδ T Cells Facilitate the Anti‐Leukemia Activity of αβ T Cells. [[{“value”:”Keli Yue, Shuang Liang, Ning Wu, Mingzhu Jia, Haitao Gao, Cong Cheng, Lijuan Hu, Jiangying Liu”}]]

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• Dysregulated HLA-DR expression on γδ T cells and impaired functionality of αβ T cells were found in the bone marrows of AML patients. • The ex vivo-expanded donor γδ T cells with high expression of HLA-DR facilitated the cytotoxic effect of αβ T cells. ABSTRACT In addition to exhibiting significant cytotoxic capabilities, γδ T … Read more

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis. [[{“value”:”Sarah Schmidiger, Erin F. McCaffrey, Jan M. Schmidt, Owais Abdul Hameed, Max Mpina, Anneth Tumbo, Elirehema Mfinanga, Frederick Haraka, Hellen Hiza, Mohamed Sasamalo, Jerry Hella, Michael Walch, Jacques Fellay, Sébastien Gagneux, Klaus Reither, José M. Carballido, Ainhoa Arbués, Damien Portevin”}]]

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Exploiting a high-dimensional mass cytometry approach, we demonstrate that CD56+ lymphocytes promote Mycobacterium tuberculosis dormancy by delivering granulysin, a cytotoxic effector molecule with known antimicrobial activity. ABSTRACT Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an … Read more

Suppressor of Cytokine Signaling Mimetics as a Therapeutic Approach in Autoimmune Encephalitis. [[{“value”:”Rahul Pandey, Marina Bakay, Hakon Hakonarson”}]]

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SOCS mimetics target dysregulated cytokine signaling, offering promising immunomodulatory therapy for autoimmune encephalitis by suppressing cytokine signaling, reducing neuroinflammation, and preserving blood–brain barrier integrity. ABSTRACT Autoimmune encephalitis (AE) is a debilitating neurological condition characterized by the immune system’s attack on neuronal cells, often leading to significant cognitive and neurological impairments. Autoantibodies, particularly those targeting N-methyl-D-aspartate … Read more

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