European Journal of Immunology

Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate. [[{“value”:”Fabian Guendel, Emelyne Lécuyer”}]]

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Innate lymphoid cells (ILCs) have emerged as critical regulators of immune defense, tissue repair, and metabolic homeostasis. By integrating environmental cues, they orchestrate tissue-specific metabolic adaptation. This review discusses ILC functions in adult energy regulation and proposes that neonatal ILCs play essential roles in postnatal metabolic and tissue maturation. ABSTRACT In the almost two decades … Read more

Cover Story: Eur. J. Immunol. 11’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV‐Specific CD8+ T Cells. [[{“value”:”Varun Sasidharan Nair, Zheng Yu, Hosein Ahmadi, Agnes Bonifacius, Beate Pietzsch, Dirk H. Busch, Luka Cicin‐Sain, Fabian Müller, Kilian Schober, Britta Eiz‐Vesper, Stefan Floess, Jochen Huehn”}]]

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Differentially methylated regions (DMRs) within the ZEB2 locus progressively demethylate during CD4+ and CD8+ T cell differentiation into cytotoxic CD4+ and CD8+ TEMRA subsets, respectively. This epigenetic remodeling tightly correlates with elevated ZEB2 expression, and ZEB2 knockout (KO) impairs the effector and cytotoxic function of CD4+ and CD8+ T cells. ABSTRACT Zinc finger E-box binding … Read more

Induction of Tolerogenic Dendritic Cells by a Noncoding Oligonucleotide. [[{“value”:”Kahkashan Kamal, James Trumbo, Elina Richardsdotter‐Andersson, Marie Wahren‐Herlenius, Anna‐Lena Spetz”}]]

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In this article, the authors elucidated the immunoregulatory role of an oligonucleotide (ssON) that favors the induction of human tolerogenic dendritic cells (DC). The tolerogenic profile was evidenced by reduced responsiveness to lipopolysaccharides (LPS) (A). Importantly, the tolerogenic DCs had upregulated PD-L1 molecules and functionally inhibited the proliferation of alloreactive T cells and induced FoxP3+ … Read more

Administration of the NOD2 Agonist MDP Reduces Cryptosporidium parvum Infection in Neonatal Mice Through IL‐22 Involvement. [[{“value”:”Mégane Fernandez, Tiffany Pezier, Julien Pichon, Yves Le Vern, Catherine Werts, Sonia Lacroix‐Lamandé”}]]

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Neonatal mice infected with C. parvum and treated with MDP, a NOD2 agonist, exhibited reduced intestinal infection. This protective effect was mediated by a local immune response involving neutrophil recruitment, IL-22 production, antimicrobial peptide expression, and epithelial regeneration in an IFN-γ-dependent manner. Therefore, MDP administration enhances host defense mechanisms against C. parvum infection in neonatal … Read more

Identification and Functional Validation of Novel Pathogenic Variants in Primary Immunodeficiencies. [[{“value”:”Arvinden VR, Geeta Madathil Govindaraj, Aditya Ramdas Iyer, Sangita Paul, Athulya Edavazhippurath, Abhinav Jain, Pragya Gupta, Gauspasha Yusuf Deshmukh, Shivani Singh, Vinodh Saravanakumar, Juhi Bhardwaj, Srishti Sharma, Tancia P. Benny, Priya Saravanan, Rahul C. Bhoyar, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Harie Vignesh, Bani Jolly, Aparna Dalvi, Umair Ahmed Bargir, Manisha Madkaikar, Binukumar BK, Sridhar Sivasubbu, Sivaprakash Ramalingam, Vinod Scaria”}]]

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Primary immunodeficiency is a monogenic disorder that affects proper immune functioning. Diagnostic yield of these inherited diseases are burdened by the presence of variants of unknown significance. In this study we functionally validated novel variants associated with immunodeficiency to ascertain its pathogenicity. ABSTRACT Primary immunodeficiency diseases (PIDs) are inherited disorders caused by genetic defects affecting … Read more

LILRA5 Functions to Induce ROS Production on Innate Immune Cells. [[{“value”:”Zuyi Fu, Matevž Rumpret, Irina Kube‐Golovin, Mykola Lyndin, Vera Solntceva, Yuxi Zhao, Anastasia Konieva, Na Liu, Adrian T. Press, Stefanie B. Flohé, Michael Bauer, Gunther Wennemuth, Bernhard B Singer, Alex J. McCarthy”}]]

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Ligation of the activating LILRA5 receptor specifically stimulates ROS production by monocytes and neutrophils. Though LILRA5 transcripts are upregulated upon immune stimulation, surface LILRA5 expressions are dynamically regulated. Enhanced soluble LILRA5 was observed during immune challenge, suggesting that dynamic regulation of LILRA5 modulates ROS induction and innate immune responses. ABSTRACT Activating immune receptors provides mechanisms … Read more

CD16A Shedding Regulates Innate Cell Engager‐Induced Serial Killing by Natural Killer Cells. [[{“value”:”Chiara Zambarda, Karolin Guldevall, Christian Breunig, Damien Toullec, Patrick A. Sandoz, Valentina Carannante, Shanshan Xu, Patrick Ross, Kyra Kuhnigk, Niklas Sandström, Jacopo Fontana, Susanne Wingert, Sheena Pinto, Julia Knoch, Alamdar Hussain, Arnika K. Wagner, Jens Pahl, Evren Alici, Joachim Koch, Björn Önfelt”}]]

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NK cells kill tumor targets via antibody-dependent cellular cytotoxicity (ADCC), mediated by the receptor CD16A. We show that the bispecific innate cell engager acimtamig (AFM13) enhances ADCC and boosts NK cell serial killing. Live-cell imaging revealed that CD16A shedding is essential for efficient NK cell detachment and sustained killing. ABSTRACT Natural killer (NK) cells can … Read more

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